Gastric cancer in young patients: Demographic, clinicopathological, and prognostic factors in 92 patients Journal Article
| Authors: | Koea, J. B.; Karpeh, M. S.; Brennan, M. F. |
| Article Title: | Gastric cancer in young patients: Demographic, clinicopathological, and prognostic factors in 92 patients |
| Abstract: | Background: This investigation was undertaken to define the demographic, clinicopathological, and prognostic factors relevant to young patients with gastric adenocarcinoma. Methods: A prospective database of all patients with gastric cancer who presented to Memorial Sloan-Kettering Cancer Center was started in 1985. Clinical, pathological, and operative records and follow-up data on 92 patients, 40 years of age or younger, with a primary diagnosis of gastric cancer were reviewed. Results: The mean patient age was 35 ± 4.9 years (range, 17-40 years), and 52 were male. The male-to-female ratio of patients younger than 30 was 0.85/1; whereas in those older than 30, the ratio was 1.45/1. Sixty-six percent of the patients were white, 15% Asian, 11% Hispanic, and 8% were black American. Nineteen percent of patients reported a family history of gastric cancer. Sixty-six patients (71%) presented with stage III or IV disease, whereas 13 patients, each, presented with stage I or II disease. Poorly differentiated lesions were present in 71%. Resection with curative intent was undertaken in 47 patients, and resection with palliative intent was performed in 24 patients. Tumor site (proximal vs. distal vs. linitus plastica), advanced T stage, and the presence of nodal disease were significant predictors of disease-free survival on both univariate and multivariate analyses. The mean survival time and disease-specific 5-year survival rates for individual Union International Contre le Cancer tumor stages were similar to those observed in older populations of patients with gastric cancer; and eight patients, who presented with early (T1/T2) node-negative tumors, are alive and well a minimum of 60 months after resection. Conclusions: The high frequency of a positive family history in young patients suggests an opportunity to identify a high-risk population for screening. |
| Keywords: | adolescent; adult; cancer survival; survival analysis; survival rate; major clinical study; cancer staging; prospective studies; adenocarcinoma; demography; risk factors; cancer screening; survival time; stomach cancer; high risk population; stomach adenocarcinoma; databases, factual; age of onset; stomach neoplasms; gastric cancer; cancer family; humans; prognosis; human; male; female; article; familial screening |
| Journal Title: | Annals of Surgical Oncology |
| Volume: | 7 |
| Issue: | 5 |
| ISSN: | 1068-9265 |
| Publisher: | Springer |
| Date Published: | 2000-04-01 |
| Start Page: | 346 |
| End Page: | 351 |
| Language: | English |
| PUBMED: | 10864341 |
| PROVIDER: | scopus |
| DOI: | 10.1007/s10434-000-0346-9 |
| DOI/URL: | |
| Notes: | Export Date: 18 November 2015 -- Source: Scopus |
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