Histone methylation sets the stage for meiotic DNA breaks Journal Article
| Authors: | Kniewel, R.; Keeney, S. |
| Article Title: | Histone methylation sets the stage for meiotic DNA breaks |
| Abstract: | Covalent post-translational modifications of histones have important functions in transcription, replication, repair, and other aspects of eukaryotic chromosome dynamics. Trimethylation of lysine-4 on histone H3 is enriched at actively transcribed loci in many organisms. The impact of this histone modification on transcription has been extensively studied, but less is known about its effects on other chromosomal processes. An intriguing new study in this issue of EMBO Journal demonstrates that H3 lysine-4 trimethylation is critical in budding yeast for formation of the programmed DNA double-strand breaks that initiate homologous recombination during meiosis. These findings have important implications for elucidating the previously recognized but little understood connections between meiotic break formation and transcriptional promoters in this organism. © 2009 European Molecular Biology Organization | All Rights Reserved. |
| Keywords: | methylation; nonhuman; meiosis; homologous recombination; dna repair; dna; saccharomyces cerevisiae; eukaryota; recombination, genetic; histone h3; dna breaks, double-stranded; double stranded dna break; dna structure; yeast; saccharomycetales; histones; lysine; dna transcription; protein methylation; gene expression regulation, fungal |
| Journal Title: | EMBO Journal |
| Volume: | 28 |
| Issue: | 2 |
| ISSN: | 0261-4189 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2009-01-21 |
| Start Page: | 81 |
| End Page: | 83 |
| Language: | English |
| DOI: | 10.1038/emboj.2008.277 |
| PUBMED: | 19158660 |
| PROVIDER: | scopus |
| PMCID: | PMC2634739 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 4" - "Export Date: 30 November 2010" - "CODEN: EMJOD" - "Source: Scopus" |
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