Toward precision medicine in glioblastoma: The promise and the challenges Journal Article
| Authors: | Prados, M. D.; Byron, S. A.; Tran, N. L.; Phillips, J. J.; Molinaro, A. M.; Ligon, K. L.; Wen, P. Y.; Kuhn, J. G.; Mellinghoff, I. K.; De Groot, J. F.; Colman, H.; Cloughesy, T. F.; Chang, S. M.; Ryken, T. C.; Tembe, W. D.; Kiefer, J. A.; Berens, M. E.; Craig, D. W.; Carpten, J. D.; Trent, J. M. |
| Article Title: | Toward precision medicine in glioblastoma: The promise and the challenges |
| Abstract: | Integrated sequencing strategies have provided a broader understanding of the genomic landscape and molecular classifications of multiple cancer types and have identified various therapeutic opportunities across cancer subsets. Despite pivotal advances in the characterization of genomic alterations in glioblastoma, targeted agents have shown minimal efficacy in clinical trials to date, and patient survival remains poor. In this review, we highlight potential reasons why targeting single alterations has yielded limited clinical efficacy in glioblastoma, focusing on issues of tumor heterogeneity and pharmacokinetic failure. We outline strategies to address these challenges in applying precision medicine to glioblastoma and the rationale for applying targeted combination therapy approaches that match genomic alterations with compounds accessible to the central nervous system. |
| Keywords: | clinical trial; glioblastoma; genomics; tyrosine kinase inhibitor; therapy; targeted; malignant glioma; recurrent; progression-free survival; convection-enhanced delivery; randomized phase-iii; factor receptor inhibitors; adjuvant temozolomide; brain-tumor consortium; newly-diagnosed glioblastoma; integrated genomic analysis; precision medicine |
| Journal Title: | Neuro-Oncology |
| Volume: | 17 |
| Issue: | 8 |
| ISSN: | 1522-8517 |
| Publisher: | Oxford University Press |
| Date Published: | 2015-08-01 |
| Start Page: | 1051 |
| End Page: | 1063 |
| Language: | English |
| ACCESSION: | WOS:000361305700003 |
| DOI: | 10.1093/neuonc/nov031 |
| PROVIDER: | wos |
| PMCID: | PMC4490873 |
| PUBMED: | 25934816 |
| Notes: | Article -- Source: Wos |
