Creation of a histone deacetylase 6 inhibitor and its biological effects Journal Article

   


Authors: Lee, J. H.; Yao, Y.; Mahendran, A.; Ngo, L.; Venta-Perez, G.; Choy, M. L.; Breslow, R.; Marks, P. A.
Article Title: Creation of a histone deacetylase 6 inhibitor and its biological effects
Abstract: We report the development of a potent, selective histone deacetylase 6 (HDAC6) inhibitor. This HDAC6 inhibitor blocks growth of normal and transformed cells but does not induce death of normal cells. The HDAC6 inhibitor alone is as effective as paclitaxel in anticancer activity in tumor-bearing mice.
Keywords: controlled study; unclassified drug; human cell; histone deacetylase inhibitor; nonhuman; paclitaxel; mouse; cell viability; dna repair; cell growth; animal experiment; animal model; antineoplastic activity; cytotoxicity; drug potency; drug synthesis; dna; cell transformation; tubulin; skin fibroblast; growth inhibition; histone deacetylase 6; hdac; cancer; human; male; priority journal; article; lncap cell line; n hydroxy 4 [[n (2 hydroxyethyl) 2 phenylacetamido]methyl]benzamide
Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Volume: 112
Issue: 39
ISSN: 0027-8424
Publisher: National Academy of Sciences  
Date Published: 2015-09-29
Start Page: 12005
End Page: 12010
Language: English
DOI: 10.1073/pnas.1515882112
PROVIDER: scopus
PMCID: PMC4593111
PUBMED: 26371309
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-84942847632&partnerID=40&md5=3658b5768a5babef40637194598f537c
Notes: Export Date: 2 November 2015 -- Source: Scopus
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MSK Authors
  1. Lang Ngo
    27 Ngo
  2. Gisela Venta-Perez
    23 Venta-Perez
  3. Ju-Hee Lee
    9 Lee
  4. Megan Lee Choy
    6 Choy
  5. Paul Marks
    186 Marks
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