The tumoral and stromal immune microenvironment in malignant pleural mesothelioma: A comprehensive analysis reveals prognostic immune markers Journal Article
| Authors: | Ujiie, H.; Kadota, K.; Nitadori, J. I.; Aerts, J. G.; Woo, K. M.; Sima, C. S.; Travis, W. D.; Jones, D. R.; Krug, L. M.; Adusumilli, P. S. |
| Article Title: | The tumoral and stromal immune microenvironment in malignant pleural mesothelioma: A comprehensive analysis reveals prognostic immune markers |
| Abstract: | Antitumor immune responses against solid malignancies correlate with improved patient survival. We conducted a comprehensive investigation of immune responses in tumor and tumor-associated stroma in epithelioid malignant pleural mesothelioma with the goal of characterizing the tumor immune microenvironment and identifying prognostic immune markers. We investigated 8 types of tumor-infiltrating immune cells within the tumor nest and tumor-associated stroma, as well as tumor expression of 5 cytokine/chemokine receptors in 230 patients. According to univariate analyses, high densities of tumoral CD4- and CD20-expressing lymphocytes were associated with better outcomes. High expression of tumor interleukin-7 (IL-7) receptor was associated with worse outcomes. According to multivariate analyses, stage and tumoral CD20 detection were independently associated with survival. Analysis of single immune cell infiltration for CD163+ tumor-associated macrophages did not correlate with survival. However, analysis of immunologically relevant cell combinations identified that: (1) high CD163+ tumor-associated macrophages and low CD8+ lymphocyte infiltration had worse prognosis than other groups and (2) low CD163+ tumor associated macrophages and high CD20+ lymphocyte infiltration had better prognosis than other groups. Multivariate analyses demonstrated that CD163/CD8 and CD163/CD20 were independent prognostic factors of survival. With a recent increase in immunotherapy investigations and clinical trials for malignant pleural mesothelioma patients, our observations that CD20+ B lymphocytes and tumor-associated macrophages are prognostic markers provide important information about the tumor microenvironment of malignant pleural mesothelioma. © 2015, Taylor & Francis Group, LLC. |
| Keywords: | b lymphocyte; t lymphocytes; tumor-infiltrating lymphocytes; immune responses to cancer; pleural malignancy |
| Journal Title: | OncoImmunology |
| Volume: | 4 |
| Issue: | 6 |
| ISSN: | 2162-4011 |
| Publisher: | Landes Bioscience |
| Date Published: | 2015-06-01 |
| Start Page: | e1009285 |
| Language: | English |
| DOI: | 10.1080/2162402x.2015.1009285 |
| PROVIDER: | scopus |
| PMCID: | PMC4485766 |
| PUBMED: | 26155428 |
| DOI/URL: | |
| Notes: | Export Date: 2 November 2015 -- Source: Scopus |
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