Therapeutic effects of repurposed therapies in non-small cell lung cancer: What is old is new again Journal Article
| Authors: | Saxena, A.; Becker, D.; Preeshagul, I.; Lee, K.; Katz, E.; Levy, B. |
| Article Title: | Therapeutic effects of repurposed therapies in non-small cell lung cancer: What is old is new again |
| Abstract: | The recent emergence of targeted and immunotherapeutic agents has dramatically changed the management for patients with non-small cell lung cancer (NSCLC). Despite these advances, lung cancer is not exempt from the challenges facing oncology drug development, including the huge financial cost and the time required for drug implementation. Repositioning noncancer therapies with potential antineoplastic properties into new therapeutic niches is an alternative treatment strategy offering the possibility of saving money and time and improving outcomes. The goal of such a strategy is to deliver an effective drug with a favorable toxicity profile at a reduced cost. Preclinical models and observational data have demonstrated promising activity for many of these agents, and they are now being studied in prospective trials. We review the relevant published data regarding the therapeutic effects of metformin, statins, nonsteroidal anti-inflammatory drugs, b-blockers, and itraconazole in NSCLC, with a focus on the putative mechanisms of action and clinical data. As these drugs are increasingly being tested in clinical trials, we aim to highlight the salient challenges and future strategies to optimize this approach. © AlphaMed Press. |
| Keywords: | signal transduction; protein kinase b; treatment outcome; gene mutation; constipation; fatigue; hepatitis; diarrhea; gastrointestinal hemorrhage; hypertension; cancer staging; cell proliferation; metastasis; apoptosis; liver toxicity; myalgia; epidermal growth factor receptor; bradycardia; angiogenesis; protein p53; carcinogenesis; dizziness; cost effectiveness analysis; hypotension; celecoxib; cardiovascular disease; heart infarction; warfarin; nausea and vomiting; metoprolol; down regulation; cognitive defect; headache; digestive system perforation; pemetrexed; atorvastatin; metformin; simvastatin; non insulin dependent diabetes mellitus; non-small cell lung cancer; oxidative phosphorylation; cerebrovascular accident; bronchospasm; itraconazole; grapefruit juice; abdominal discomfort; cimetidine; non small cell lung cancer; phase 2 clinical trial (topic); reduced nicotinamide adenine dinucleotide dehydrogenase (ubiquinone); hypersensitivity; hydroxymethylglutaryl coenzyme a reductase kinase; megaloblastic anemia; statins; human; priority journal; article; drug repositioning; nonsteroidal anti-inflammatory drug; β-blocker; apricoxib; lactic acidosis |
| Journal Title: | The Oncologist |
| Volume: | 20 |
| Issue: | 8 |
| ISSN: | 1083-7159 |
| Publisher: | Oxford University Press |
| Date Published: | 2015-08-01 |
| Start Page: | 934 |
| End Page: | 945 |
| Language: | English |
| DOI: | 10.1634/theoncologist.2015-0064 |
| PROVIDER: | scopus |
| PMCID: | PMC4524771 |
| PUBMED: | 26156329 |
| DOI/URL: | |
| Notes: | Export Date: 2 October 2015 -- Source: Scopus |
