DNA methylation pathways and their crosstalk with histone methylation Journal Article
| Authors: | Du, J.; Johnson, L. M.; Jacobsen, S. E.; Patel, D. J. |
| Article Title: | DNA methylation pathways and their crosstalk with histone methylation |
| Abstract: | Methylation of DNA and of histone 3 at Lys 9 (H3K9) are highly correlated with gene silencing in eukaryotes from fungi to humans. Both of these epigenetic marks need to be established at specific regions of the genome and then maintained at these sites through cell division. Protein structural domains that specifically recognize methylated DNA and methylated histones are key for targeting enzymes that catalyse these marks to appropriate genome sites. Genetic, genomic, structural and biochemical data reveal connections between these two epigenetic marks, and these domains mediate much of the crosstalk. © 2015 Macmillan Publishers Limited. All rights reserved. |
| Keywords: | signal transduction; nonhuman; cell division; dna methylation; eukaryota; epigenetics; mammal; histone h3; genomics; genome; gene silencing; catalysis; protein structure; fungus; fungi; dna methyltransferase 1; eukaryote; life cycle; histone methylation; biochemical analysis; arabidopsis thaliana; neurospora crassa; human; priority journal; article |
| Journal Title: | Nature Reviews Molecular Cell Biology |
| Volume: | 16 |
| Issue: | 9 |
| ISSN: | 1471-0072 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2015-09-01 |
| Start Page: | 519 |
| End Page: | 532 |
| Language: | English |
| DOI: | 10.1038/nrm4043 |
| PROVIDER: | scopus |
| PUBMED: | 26296162 |
| PMCID: | PMC4672940 |
| DOI/URL: | |
| Notes: | Export Date: 2 October 2015 -- Source: Scopus |
