Glandular differentiation in dedifferentiated chondrosarcoma: Molecular evidence of a rare phenomenon Journal Article
| Authors: | Jour, G.; Liu, Y.; Ricciotti, R.; Pritchard, C.; Hoch, B. L. |
| Article Title: | Glandular differentiation in dedifferentiated chondrosarcoma: Molecular evidence of a rare phenomenon |
| Abstract: | Summary Epithelial glandular differentiation in dedifferentiated chondrosarcoma has not been described. Our patient was a 64-year-old man with a history of prostate cancer status post-radiation and hormonal therapy. On screening bone scan, he was found to have increased uptake in his right femoral shaft. Biopsy revealed intermediate-grade conventional chondrosarcoma. Subsequent femoral resection was remarkable for an intermediate-grade chondrosarcomatous component juxtaposed to an area composed of anastomosing nests and cords of malignant epithelial cells showing nuclear atypia and increased mitotic activity. A fibroblastic-appearing spindle cell population was intimately associated with the epithelial cells. The epithelial cells labeled with 34bE12, AE1/AE3, EMA, and Vimentin (both spindled and epithelial components) while being negative for prostate-specific antigen, prostate specific acid phosphatase, cytokeratin 20, thyroid transcription factor-1, and CDX2. The patient developed local recurrence 9 months after the initial resection but has had no metastatic disease and consistently undetectable prostate-specific antigen levels. Deep parallel sequencing of the dedifferentiated component showed a nonsynonymous mutation at exon 4 of IDH1 gene at codon R132 leading to a substitution of arginine, with serine confirming glandular differentiation in dedifferentiated chondrosarcoma. © 2015 Elsevier Inc. |
| Keywords: | immunohistochemistry; adult; human tissue; middle aged; cancer surgery; gene mutation; exon; histopathology; case report; multimodality cancer therapy; cancer radiotherapy; nuclear magnetic resonance imaging; follow up; cd34 antigen; metastasis; tumor differentiation; cytogenetics; cell population; cancer hormone therapy; prostate cancer; gleason score; microarray analysis; tumor recurrence; epithelium cell; spindle cell; mitosis rate; hospital readmission; codon; chondrosarcoma; oncogene myc; bone scintiscanning; total knee replacement; chromosome 8q; cytokeratin ae1; cytokeratin ae3; vimentin; smooth muscle actin; chromosome 9; medical history; bone biopsy; chromosome 15; next generation sequencing; human; male; article; dedifferentiated chondrosarcoma; mesenchymal epithelial transition; cytogenomic microarray; epithelial glandular differentiation; femur shaft |
| Journal Title: | Human Pathology |
| Volume: | 46 |
| Issue: | 9 |
| ISSN: | 0046-8177 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2015-09-01 |
| Start Page: | 1398 |
| End Page: | 1404 |
| Language: | English |
| DOI: | 10.1016/j.humpath.2015.05.018 |
| PROVIDER: | scopus |
| PUBMED: | 26198745 |
| DOI/URL: | |
| Notes: | Export Date: 2 October 2015 -- Source: Scopus |
