Authors: | Guryanova, O. A.; Levine, R. L. |
Article Title: | A WIMSical approach to decoding DNA methylation in myeloid leukemia |
Abstract: | Integrated transcriptomic and high-resolution whole genome methylation analysis in a myeloid leukemia cell line defines genes that respond to clinically relevant DNA methyltransferase inhibitors. © 2014 Guryanova and Levine; licensee BioMed Central. |
Keywords: | gene mutation; drug efficacy; outcome assessment; dna damage; gene targeting; transcriptomics; dna methylation; genome analysis; tumor suppressor gene; myelodysplastic syndrome; dna; transcription regulation; drug mechanism; epigenetics; gene identification; nucleotide sequence; acute myeloblastic leukemia; hematopoietic stem cell; gene silencing; azacitidine; genetic parameters; dna methyltransferase 3a; genetic regulation; dna methyltransferase inhibitor; decitabine; human; article; myeloid leukemia cell line; washington university interpolated methylation signatures |
Journal Title: | Genome Biology |
Volume: | 15 |
Issue: | 8 |
ISSN: | 1465-6906 |
Publisher: | Biomed Central Ltd |
Date Published: | 2014-09-02 |
Start Page: | 441 |
Language: | English |
DOI: | 10.1186/s13059-014-0441-z |
PROVIDER: | scopus |
PMCID: | PMC4397946 |
PUBMED: | 25315876 |
DOI/URL: | |
Notes: | Export Date: 2 October 2015 -- Source: Scopus |