Targeting breast cancer metastasis Journal Article
| Authors: | Jin, X.; Mu, P. |
| Article Title: | Targeting breast cancer metastasis |
| Abstract: | Metastasis is the leading cause of breast cancer-associated deaths. Despite the significant improvement in current therapies in extending patient life, 30-40% of patients may eventually suffer from distant relapse and succumb to the disease. Consequently, a deeper understanding of the metastasis biology is key to developing better treatment strategies and achieving long-lasting therapeutic efficacies against breast cancer. This review covers recent breakthroughs in the discovery of various metastatic traits that contribute to the metastasis cascade of breast cancer, which may provide novel avenues for therapeutic targeting. © the authors, publisher and licensee Libertas Academica Limited. |
| Keywords: | signal transduction; protein expression; gene mutation; drug safety; treatment planning; bone metastasis; drug targeting; outcome assessment; metastasis; breast cancer; gene amplification; epidermal growth factor receptor 2; gene function; enzyme activation; carcinogenesis; cancer resistance; cancer hormone therapy; cancer genetics; stroma; targeted therapy; cancer classification; estrogen receptor; drug sensitivity; tumor microenvironment; clinical trial (topic); molecularly targeted therapy; epithelial mesenchymal transition; metastasis inhibition; tumor invasion; oncological parameters; intratumor heterogeneity; human; article; precision medicine; metastatic traits; estrogen receptor antagonist |
| Journal Title: | Breast Cancer: Basic and Clinical Research |
| Volume: | 9 |
| Issue: | Suppl. 1 |
| ISSN: | 1178-2234 |
| Publisher: | Sage Publications |
| Date Published: | 2015-01-01 |
| Start Page: | 23 |
| End Page: | 34 |
| Language: | English |
| DOI: | 10.4137/bcbcr.s25460 |
| PROVIDER: | scopus |
| PMCID: | PMC4559199 |
| PUBMED: | 26380552 |
| DOI/URL: | |
| Notes: | Export Date: 2 October 2015 -- Source: Scopus |
