Arrhythmias in the setting of hematopoietic cell transplants Journal Article
| Authors: | Tonorezos, E. S.; Stillwell, E. E.; Calloway, J. J.; Glew, T.; Wessler, J. D.; Rebolledo, B. J.; Pham, A.; Steingart, R. M.; Lazarus, H.; Gale, R. P.; Jakubowski, A. A.; Schaffer, W. L. |
| Article Title: | Arrhythmias in the setting of hematopoietic cell transplants |
| Abstract: | Prior studies report that 9-27% of persons receiving a hematopoietic cell transplant develop arrhythmias, but the effect on outcomes is largely unknown. We reviewed data from 1177 consecutive patients ≥40 years old receiving a hematopoietic cell transplant at one center during 1999-2009. Transplant indication was predominately leukemia, lymphoma and multiple myeloma. Overall, 104 patients were found to have clinically significant arrhythmia: 43 before and 61 after transplant. Post-transplant arrhythmias were most frequently atrial fibrillation (N=30), atrial flutter (N=7) and supraventricular tachycardia (N=11). Subjects with an arrhythmia post transplant were more likely to have longer median hospital stays (32 days vs 23, P=<0.001), a greater probability of an intensive care unit admission (52% vs 7%; P<0.001), greater probability of in-hospital deaths (28% vs 3%, P<0.001), and greater probability of death within 1 year of transplant (41% vs 15%; P<0.001) compared with patients without arrhythmia at any time. In a multivariate model including age at transplant, diagnosis, history of pretransplant arrhythmia, and transplant-related variables, post-transplant arrhythmia was associated with a greater risk for death within a year of transplant (odds ratio 3.5, 95% confidence interval: 2.1, 5.9; P<0.001). Our data suggest that arrhythmias after transplants are associated with significant morbidity and mortality. A prospective study of arrhythmia in the transplant setting is warranted. © 2015 Macmillan Publishers Limited. All rights reserved. |
| Keywords: | adult; aged; leukemia; major clinical study; mortality; disease association; multiple myeloma; hematopoietic stem cell transplantation; risk factor; intensive care unit; length of stay; myelodysplastic syndrome; whole body radiation; lymphoma; graft versus host reaction; allogeneic hematopoietic stem cell transplantation; heart arrhythmia; t cell depletion; atrial fibrillation; autologous hematopoietic stem cell transplantation; supraventricular tachycardia; thymocyte antibody; human; male; female; priority journal; article |
| Journal Title: | Bone Marrow Transplantation |
| Volume: | 50 |
| Issue: | 9 |
| ISSN: | 0268-3369 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2015-09-01 |
| Start Page: | 1212 |
| End Page: | 1216 |
| Language: | English |
| DOI: | 10.1038/bmt.2015.127 |
| PROVIDER: | scopus |
| PMCID: | PMC4558298 |
| PUBMED: | 26030046 |
| DOI/URL: | |
| Notes: | Export Date: 2 October 2015 -- Source: Scopus |
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455Jakubowski -
83Tonorezos
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