UPR(mt)-mediated cytoprotection and organismal aging Journal Article


Authors: Schulz, A. M.; Haynes, C. M.
Article Title: UPR(mt)-mediated cytoprotection and organismal aging
Abstract: Time- or age-dependent accumulation of mitochondrial damage and dysfunction is strongly associated with aging [1]. Thus, a major biomedical goal is to identify and therapeutically manipulate those inherent programs that protect against mitochondrial dysfunction to promote cell survival and organismal health. The mitochondrial unfolded protein response (UPRmt) is such a protective transcriptional response mediated by mitochondrial-to-nuclear signaling that includes mitochondrial proteostasis genes to stabilize mitochondrial function, metabolic adaptations, as well as an innate immunity program. Here, we review the UPRmt and its role during a variety of forms of mitochondrial dysfunction including those caused by mutations in respiratory chain genes as well as upon exposure to pathogens that produce mitochondrial toxins. We also review recent data in support of and against the emerging role of the UPRmt during aging and longevity. This article is part of a Special Issue entitled: Mitochondrial Dysfunction in Aging. © 2015 Elsevier B.V. All rights reserved.
Keywords: signal transduction; protein phosphorylation; gene mutation; nonhuman; protein function; animal cell; metabolism; dna repair; protein synthesis; innate immunity; aging; cholesterol; lactate dehydrogenase; caenorhabditis elegans; heat shock protein 70; mitochondrial protein; cell communication; cell protection; loss of function mutation; mitochondrion; glycolysis; somatomedin binding protein; cell stress; genotoxicity; mitochondrial dna; disorders of mitochondrial functions; protein homeostasis; unfolded protein response; life extension; respiratory chain; mitochondrial dysfunction; initiation factor 2alpha; mitochondrial rna; activating transcription factor; chaperonin 60; priority journal; article; mitochondrial unfolded protein response; hydroxymethylglutaryl coenzyme a reductase; atfs-1
Journal Title: Biochimica et Biophysica Acta (BBA) - Bioenergetics
Volume: 1847
Issue: 11
ISSN: 0005-2728
Publisher: Elsevier B.V.  
Date Published: 2015-11-01
Start Page: 1448
End Page: 1456
Language: English
DOI: 10.1016/j.bbabio.2015.03.008
PROVIDER: scopus
PMCID: PMC4575829
PUBMED: 25857997
DOI/URL:
Notes: Export Date: 2 October 2015 -- Source: Scopus
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MSK Authors
  1. Cole Haynes
    24 Haynes
  2. Anna Mareike Schulz
    4 Schulz