Lymphatic mapping in endometrial cancer: From establishing feasibility to determining accuracy Journal Article

  


Authors: Khoury-Collado, F.; Abu-Rustum, N. R.
Article Title: Lymphatic mapping in endometrial cancer: From establishing feasibility to determining accuracy
Abstract: Published series of lymphatic mapping in endometrial cancer were reviewed. Techniques, results and requirements for implementation are discussed. All papers published to date contain a small number of patients and can mainly answer questions of feasibility, rather than accuracy, of the technique. Currently used techniques fall into three main categories which relate to the site of injection: subserosal, cervical and endometrial. High detection rates can be achieved in all three categories, and probably will improve as more experience is gained. The optimal technique should include mapping of the aortic nodes. The use of both radioactive and blue dye seems optimal at this time, although it may not be required in the future. Immunohistochemical staining of sentinel nodes may improve the detection of micro-metastasis in sentinel nodes, but its clinical significance remains to be determined. Meaningful sensitivity and false negative rates can only be determined to a limited extent from current series due to their small numbers and the low incidence of lymph node metastasis in early endometrial cancer. To conclude, lymphatic mapping in endometrial carcinoma is feasible. Emerging larger series and individual center experiences will continue to add to our knowledge and establish the clinical value of this technique.
Keywords: immunohistochemistry; review; nuclear magnetic resonance imaging; lymph node metastasis; cancer diagnosis; paraaortic lymph node; isosulfan blue; methylene blue; technetium 99m; endometrium cancer; sentinel lymph node; sensitivity analysis; breast cancer; ultrasound; pruritus; rash; false negative result; hypotension; micrometastasis; dye; diagnostic test; lymphatic drainage; endometrial carcinoma; allergic reaction; hysteroscopy; lymphatic mapping; radioactive material; injection site; serosa; urticaria
Journal Title: CME Journal of Gynecologic Oncology
Volume: 14
Issue: 2 Pt. 2
ISSN: 1219-9087
Publisher: Primed -X Press Publishing Ltd  
Date Published: 2009-01-01
Start Page: 56
End Page: 61
Language: English
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-77949493367&partnerID=40&md5=7141c96e91b8aece410bf2dc952395f5
Notes: --- - "Export Date: 30 November 2010" - "CODEN: CJGOF" - "Source: Scopus"