PET/CT diagnostics of prostata cancer using Bombesinanaloga Journal Article
| Authors: | Lohrmann, C.; Weber, W. |
| Article Title: | PET/CT diagnostics of prostata cancer using Bombesinanaloga |
| Abstract: | Human prostate cancers frequently express the gastrin releasing peptide receptor (GRPr), also known as Bombesin type-2 receptor. In contrast, expression levels of GRPr are low in normal and hyperplastic prostate tissue. Metabolically stable GRPr antagonists, labeled with radiometals have shown high tumor uptake in preclinical models of prostate cancer. Furthermore, these ligands demonstrated rapid clearance from normal tissues. Clinical studies have confirmed this favorable biodistribution of GRPr antagonists in patients. These studies have also provided first data on the sensitivity of GRPr PET for detection of primary and metastatic prostate cancer. This review provides a brief overview on the clinical development of GRPr ligands for PET imaging (and potentially also for radionuclide therapy) of prostate cancer. © Georg Thieme Verlag KG Stuttgart · New York. |
| Keywords: | cancer therapy; prostate cancer; computer assisted emission tomography; imaging; radioisotope therapy; pet/ct; diagnostics; human; male; article; gastrin releasing peptide receptor; bombesinanaloga |
| Journal Title: | Tumor Diagnostik und Therapie |
| Volume: | 36 |
| Issue: | 5 |
| ISSN: | 0722-219X |
| Publisher: | Georg Thieme Verlag Kg |
| Date Published: | 2015-01-01 |
| Start Page: | 283 |
| End Page: | 287 |
| Language: | German |
| DOI: | 10.1055/s-0035-1553440 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 2 September 2015 -- Source: Scopus |
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