Tumor-expressed IL-17D recruits NK cells to reject tumors Journal Article
| Authors: | Saddawi-Konefka, R.; O'sullivan, T.; Gross, E. T.; Washington, A. Jr; Bui, J. D. |
| Article Title: | Tumor-expressed IL-17D recruits NK cells to reject tumors |
| Abstract: | Antitumor immunity suppresses tumorigenesis, but we do not understand how transformed cells initiate those immune responses that are essential for effective tumor immunosurveillance. Using the 3-MCA fibrosarcoma model, we identified IL-17D as a tumor-expressed cytokine that recruits natural killer cells, leading to the polarization of M1 macrophages and tumor rejection. © 2014 Taylor & Francis Group, LLC. |
| Keywords: | nonhuman; tumor associated leukocyte; gene overexpression; cell infiltration; transforming growth factor beta; granulocyte macrophage colony stimulating factor; carcinogenesis; immune response; tumor necrosis factor alpha; microarray analysis; tumor immunity; innate immunity; tumor growth; immunosurveillance; tumor rejection; monocyte chemotactic protein 1; helper cell; natural killer t cell; antitumor immunity; tumor microenvironment; natural killer cells; interleukin 27; human; article; interleukin 17d; fibrosarcoma cell line |
| Journal Title: | OncoImmunology |
| Volume: | 3 |
| Issue: | 12 |
| ISSN: | 2162-4011 |
| Publisher: | Landes Bioscience |
| Date Published: | 2014-01-01 |
| Start Page: | e954853 |
| Language: | English |
| DOI: | 10.4161/21624011.2014.954853 |
| PROVIDER: | scopus |
| PMCID: | PMC4353093 |
| PUBMED: | 25964859 |
| DOI/URL: | |
| Notes: | Export Date: 2 September 2015 -- Source: Scopus |
