Toward understanding and exploiting tumor heterogeneity Journal Article
| Authors: | Alizadeh, A. A.; Aranda, V.; Bardelli, A.; Blanpain, C.; Bock, C.; Borowski, C.; Caldas, C.; Califano, A.; Doherty, M.; Elsner, M.; Esteller, M.; Fitzgerald, R.; Korbel, J. O.; Lichter, P.; Mason, C. E.; Navin, N.; Pe'er, D.; Polyak, K.; Roberts, C. W. M.; Siu, L.; Snyder, A.; Stower, H.; Swanton, C.; Verhaak, R. G. W.; Zenklusen, J. C.; Zuber, J.; Zucman-Rossi, J. |
| Article Title: | Toward understanding and exploiting tumor heterogeneity |
| Abstract: | The extent of tumor heterogeneity is an emerging theme that researchers are only beginning to understand. How genetic and epigenetic heterogeneity affects tumor evolution and clinical progression is unknown. The precise nature of the environmental factors that influence this heterogeneity is also yet to be characterized. Nature Medicine, Nature Biotechnology and the Volkswagen Foundation organized a meeting focused on identifying the obstacles that need to be overcome to advance translational research in and tumor heterogeneity. Once these key questions were established, the attendees devised potential solutions. Their ideas are presented here. © 2015 Nature America, Inc. All rights reserved. |
| Keywords: | disease course; review; nonhuman; biological marker; protein; practice guideline; cancer research; cell heterogeneity; cancer genetics; clinical study; dna; epigenetics; immunogenicity; tumor cell; genome; dna sequence; tumor model; tumor growth; environmental factor; non invasive procedure; translational research; tumor microenvironment; clinical trial (topic); minimally invasive procedure; cancer immunology; patient advocacy; human; priority journal |
| Journal Title: | Nature Medicine |
| Volume: | 21 |
| Issue: | 8 |
| ISSN: | 1078-8956 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2015-08-01 |
| Start Page: | 846 |
| End Page: | 853 |
| Language: | English |
| DOI: | 10.1038/nm.3915 |
| PROVIDER: | scopus |
| PUBMED: | 26248267 |
| PMCID: | PMC4785013 |
| DOI/URL: | |
| Notes: | Export Date: 2 September 2015 -- Source: Scopus |
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