Effect of acute hyperglycemia on moderately hypothermic GL261 mouse glioma monitored by T1-weighted DCE MRI Journal Article
| Authors: | Simões, R. V.; Ortuño, J. E.; Bokacheva, L.; Candiota, A. P.; Ledesma-Carbayo, M. J.; Delgado-Goñi, T.; García-Martín, M. L.; Santos, A.; Arús, C. |
| Article Title: | Effect of acute hyperglycemia on moderately hypothermic GL261 mouse glioma monitored by T1-weighted DCE MRI |
| Abstract: | Objective: We sought to evaluate the effects of acute hyperglycemia induced by intraperitoneal injection of glucose (2.7 g/kg) on vascular delivery to GL261 mouse gliomas kept at moderate hypothermia (~30 °C). Materials and methods: Seven GL261 glioma-bearing mice were studied by T1-weighted DCE MRI before and after an injection of glucose (n = 4) or saline (n = 3). Maximum relative contrast enhancement (RCE) and initial area under the enhancement curve (IAUC) were determined in each pixel. Results: The mean tumor parameter values showed no significant changes after injecting either saline (RCE −5.9 ± 5.0 %; IAUC −3.7 ± 3.6 %) or glucose (RCE −1.6 ± 9.0 %; IAUC +0.6 ± 6.4 %). Pixel-by-pixel analysis revealed small post-injection changes in RCE and IAUC between the glucose and saline groups, all within 13 % range of their baseline values. Conclusion: Perturbing the metabolism of GL261 tumors kept at moderate hypothermia with hyperglycemia did not induce significant changes in the permeability/perfusion of these tumors. This is relevant for future studies with this model since regional differences in glucose accumulation could thus reflect basal heterogeneities in vasculature and/or metabolism of GL261 tumors. © 2014, ESMRMB. |
| Keywords: | brain tumor; contrast agent; perfusion; permeability; acute hyperglycemia; gl261 cells; model-free quantification; moderate hypothermia |
| Journal Title: | Magnetic Resonance Materials in Physics, Biology and Medicine |
| Volume: | 28 |
| Issue: | 2 |
| ISSN: | 0968-5243 |
| Publisher: | ESMRMB |
| Date Published: | 2015-04-01 |
| Start Page: | 119 |
| End Page: | 126 |
| Language: | English |
| DOI: | 10.1007/s10334-014-0447-2 |
| PROVIDER: | scopus |
| PUBMED: | 24916487 |
| DOI/URL: | |
| Notes: | Export Date: 2 September 2015 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
MSK Authors
Related MSK Work