Dynamic contrast-enhanced perfusion MRI and diffusion-weighted imaging in grading of gliomas Journal Article
| Authors: | Arevalo Perez, J.; Peck, K. K. ; Young, R. J.; Holodny, A. I.; Karimi, S.; Lyo, J. K. |
| Article Title: | Dynamic contrast-enhanced perfusion MRI and diffusion-weighted imaging in grading of gliomas |
| Abstract: | PURPOSE: Accurate glioma grading is crucial for treatment planning and predicting prognosis. We performed a quantitative volumetric analysis to assess the diagnostic accuracy of histogram analysis of diffusion-weighted imaging (DWI) and dynamic contrast-enhanced (DCE) T1-weighted perfusion imaging in the preoperative evaluation of gliomas. METHODS: Sixty-three consecutive patients with pathologically confirmed gliomas who underwent baseline DWI and DCE-MRI were enrolled. The patients were classified by histopathology according to tumor grade: 20 low-grade gliomas (grade II) and 43 high-grade gliomas (grades III and IV). Volumes-of-interest were calculated and transferred to DCE perfusion and apparent diffusion coefficient (ADC) maps. Histogram analysis was performed to determine mean and maximum values for V<inf>p</inf> and K<inf>trans</inf>, and mean and minimum values for ADC. Comparisons between high-grade and low-grade gliomas, and between grades II, III, and IV, were performed. A Mann-Whitney U test at a significance level of corrected P ≤ .01 was used to assess differences. RESULTS: All perfusion parameters could differentiate between high-grade and low-grade gliomas (P < .001) and between grades II and IV, grades II and III, and grades III and IV. Significant differences in minimum ADC were also found (P < .01). Mean ADC only differed significantly between high and low grades and grades II and IV (P < .01). There were no differences between grades II and III (P = .1) and grades III and IV (P = .71). CONCLUSION: When derived from whole-tumor histogram analysis, DCE-MRI perfusion parameters performed better than ADC in noninvasively discriminating low- from high-grade gliomas. © 2015 by the American Society of Neuroimaging. |
| Keywords: | adult; controlled study; human tissue; major clinical study; histopathology; area under the curve; glioma; cancer grading; diagnostic accuracy; preoperative evaluation; sensitivity and specificity; quantitative analysis; contrast enhancement; diffusion weighted imaging; perfusion weighted imaging; diffusion coefficient; dce-mri; receiver operating characteristic; nuclear magnetic resonance scanner; volumetry; diagnostic test accuracy study; gadolinium pentetate meglumine; histogram analysis; dw-mri; human; male; female; article; glioma grading |
| Journal Title: | Journal of Neuroimaging |
| Volume: | 25 |
| Issue: | 5 |
| ISSN: | 1051-2284 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2015-09-01 |
| Start Page: | 792 |
| End Page: | 798 |
| Language: | English |
| DOI: | 10.1111/jon.12239 |
| PROVIDER: | scopus |
| PUBMED: | 25867683 |
| PMCID: | PMC5525149 |
| DOI/URL: | |
| Notes: | Export Date: 2 September 2015 -- Source: Scopus |
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