Mouse models of pancreatic ductal adenocarcinoma Journal Article
| Authors: | Ponz-Sarvise, M.; Tuveson, D. A.; Yu, K. H. |
| Article Title: | Mouse models of pancreatic ductal adenocarcinoma |
| Abstract: | Only 10% to 15% of patients with pancreatic ductal adenocarcinoma (PDAC) are candidates for potentially curative surgery due to the location or spread of disease at the time of diagnosis. Despite rapid progress in the understanding of the molecular mechanisms underlying PDAC, translation to effective therapies has been modest at best. One of the key tools available for studying biology and developing more effective therapeutics is the laboratory mouse, mus musculus. This article explores new and innovative approaches to mouse modeling and how these approaches can be utilized to move the field forward. © 2015 Elsevier Inc.. |
| Keywords: | signal transduction; cancer survival; review; nonhuman; mouse; homologous recombination; gene expression profiling; sonic hedgehog protein; rna interference; tumor xenograft; cancer research; cancer therapy; genetic engineering; pancreas adenocarcinoma; tumor immunity; hyaluronic acid; pancreatic cancer; mouse strain; kras; immunosurveillance; k ras protein; nonobese diabetic mouse; scid mouse; therapeutics; genetic heterogeneity; mouse model; tumor microenvironment; pharmacogenomics; priority journal; cancer cell line; genetic engineered mouse models; models of cancer; immortalized cell line; lsl kras g12d mouse; lsl trp53 r172h mouse |
| Journal Title: | Hematology/Oncology Clinics of North America |
| Volume: | 29 |
| Issue: | 4 |
| ISSN: | 0889-8588 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2015-08-01 |
| Start Page: | 609 |
| End Page: | 617 |
| Language: | English |
| DOI: | 10.1016/j.hoc.2015.04.010 |
| PROVIDER: | scopus |
| PUBMED: | 26226900 |
| DOI/URL: | |
| Notes: | Export Date: 2 September 2015 -- Source: Scopus |
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