Adamantinoma-like Ewing sarcoma mimicking basal cell adenocarcinoma of the parotid gland: A case report and review of the literature Journal Article

   


Authors: Lezcano, C.; Clarke, M. R.; Zhang, L.; Antonescu, C. R.; Seethala, R. R.
Article Title: Adamantinoma-like Ewing sarcoma mimicking basal cell adenocarcinoma of the parotid gland: A case report and review of the literature
Abstract: Adamantinoma-like Ewing sarcoma (AES) is a rare variant of the Ewing family of tumors that resembles classic adamantinoma of bone. AES shows epithelial differentiation and a more complex immunohistochemical expression profile with keratin and basal marker immunoreactivity and can resemble a variety of carcinomas. We report an unusual case of an AES of the parotid gland that mimicked a basal cell adenocarcinoma. Like basal cell adenocarcinoma, this AES showed a nested basaloid proliferation with peripheral palisading in tumor nests with ‘basaloid’ epithelial differentiation as highlighted by cytokeratin AE1/3 and p40 positivity. However, unlike most basal cell adenocarcinomas, this tumor demonstrated high grade morphology, showed no true ductal or myoepithelial component, and also showed a tendency towards neuroectodermal phenotype with focal rosette formation, CD99 and weak synaptophysin immunoreactivity. EWSR1 and FLI1 fluorescence in situ hybridization confirmed the presence of a translocation supporting the diagnosis of AES. This is the first case of AES presenting as a primary parotid mass highlighting the potential to be mistaken for primary salivary gland carcinomas, which in addition to basal cell adenocarcinoma include other basaloid tumors such as adenoid cystic carcinoma. © 2014, Springer Science+Business Media New York.
Keywords: ewing sarcoma; parotid; adamantinoma-like; basal cell adenocarcinoma
Journal Title: Head and Neck Pathology
Volume: 9
Issue: 2
ISSN: 1936-055X
Publisher: Humana Press Inc  
Date Published: 2015-06-01
Start Page: 280
End Page: 285
Language: English
DOI: 10.1007/s12105-014-0558-0
PROVIDER: scopus
PMCID: PMC4424212
PUBMED: 25081914
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-84939885529&partnerID=40&md5=68492566aaf6b9aee94cc346c15878fb
Notes: Export Date: 2 September 2015 -- Source: Scopus
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MSK Authors
  1. Cristina R Antonescu
    895 Antonescu
  2. Lei Zhang
    194 Zhang
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