Systematic identification of cancer driving signaling pathways based on mutual exclusivity of genomic alterations Journal Article
| Authors: | Babur, Ö; Gönen, M.; Aksoy, B. A.; Schultz, N.; Ciriello, G.; Sander, C.; Demir, E. |
| Article Title: | Systematic identification of cancer driving signaling pathways based on mutual exclusivity of genomic alterations |
| Abstract: | We present a novel method for the identification of sets of mutually exclusive gene alterations in a given set of genomic profiles. We scan the groups of genes with a common downstream effect on the signaling network, using a mutual exclusivity criterion that ensures that each gene in the group significantly contributes to the mutual exclusivity pattern. We test the method on all available TCGA cancer genomics datasets, and detect multiple previously unreported alterations that show significant mutual exclusivity and are likely to be driver events. © 2015 Babur et al.; licensee BioMed Central. |
| Keywords: | controlled study; gene mutation; neoplasm; genetic association; computer interface; cancer genetics; statistical analysis; probability; data analysis; computer simulation; computer graphics; data analysis software; genetic database; genetic algorithm; computer analysis; statistical concepts; web browser; mutual exclusivity; article; clinical data repository |
| Journal Title: | Genome Biology |
| Volume: | 16 |
| Issue: | 1 |
| ISSN: | 1465-6906 |
| Publisher: | Biomed Central Ltd |
| Date Published: | 2015-02-26 |
| Start Page: | 45 |
| Language: | English |
| DOI: | 10.1186/s13059-015-0612-6 |
| PROVIDER: | scopus |
| PMCID: | PMC4381444 |
| PUBMED: | 25887147 |
| DOI/URL: | |
| Notes: | Export Date: 2 September 2015 -- Source: Scopus |
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