Interreader and inter-test agreement in assessing treatment response following transarterial embolization for hepatocellular carcinoma Journal Article


Authors: Donati, O. F.; Do, R. K. G.; Hötker, A. M.; Katz, S. S.; Zheng, J.; Moskowitz, C. S.; Beattie, C.; Brown, K. T.
Article Title: Interreader and inter-test agreement in assessing treatment response following transarterial embolization for hepatocellular carcinoma
Abstract: Purpose: To evaluate interreader and inter-test agreement in applying size- and necrosis-based response assessment criteria after transarterial embolization (TAE) for hepatocellular carcinoma (HCC), applying two different methods of European Association for the Study of the Liver (EASL) criteria. Methods: Seventy-four patients (median age, 67 years) from a prospectively accrued study population were included in this retrospective study. Four radiologists independently evaluated CT data at 2–3 (1st follow-up, FU) and 10–12 (2nd FU) weeks after TAE and assessed treatment response using size-based (WHO, RECIST) and necrosis-based (mRECIST, EASL) criteria. Enhancing tissue was bidimensionally measured (EASL<inf>meas</inf>) and also visually estimated (EASL<inf>est</inf>). Interreader and inter-test agreements were assessed using intraclass correlation coefficient (ICC) and κ statistics. Results: Interreader agreement for all response assessment methods ranged from moderate to substantial (κ = 0.578–0.700) at 1st FU and was substantial (κ = 0.716–0.780) at 2nd FU. Inter-test agreement was substantial between WHO and RECIST (κ = 0.610–0.799, 1st FU; κ = 0.655–0.782, 2nd FU) and excellent between EASL<inf>meas</inf> and EASL<inf>est</inf> (κ = 0.899–0.918, 1st FU; κ = 0.843–0.877, 2nd FU). Conclusion: Size- and necrosis-based criteria both show moderate to excellent interreader agreement in evaluating treatment response after TAE for HCC. Inter-test agreement regarding EASL<inf>meas</inf> and EASL<inf>est</inf> was excellent, suggesting that either may be used. Key points: • Applying EASL criteria, visual estimation and bidimensional measurements show comparable interreader agreement. • EASL<inf>meas</inf>and EASL<inf>est</inf>show substantial interreader agreement for treatment response in HCC. • Agreement was excellent for EASL<inf>meas</inf>and EASL<inf>est</inf>after TAE of HCC. • Visual estimation of enhancement is adequate to assess treatment response of HCC. © 2015, European Society of Radiology.
Keywords: adult; controlled study; treatment response; aged; major clinical study; hepatocellular carcinoma; doxorubicin; artificial embolism; liver cell carcinoma; nuclear magnetic resonance imaging; follow up; randomized controlled trial; retrospective study; necrosis; response assessment; embolization; human; male; female; priority journal; article; transarterial embolization; embolic particle; interreader agreement; transarterial therapy
Journal Title: European Radiology
Volume: 25
Issue: 9
ISSN: 0938-7994
Publisher: Springer  
Date Published: 2015-09-01
Start Page: 2779
End Page: 2788
Language: English
DOI: 10.1007/s00330-015-3677-4
PROVIDER: scopus
PUBMED: 25850892
PMCID: PMC4968871
DOI/URL:
Notes: Export Date: 2 September 2015 -- Source: Scopus
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MSK Authors
  1. Junting Zheng
    200 Zheng
  2. Seth Stephen Katz
    22 Katz
  3. Chaya S. Moskowitz
    281 Moskowitz
  4. Kinh Gian Do
    257 Do
  5. Karen T Brown
    178 Brown
  6. Olivio Fabrizio Manolo Donati
    17 Donati
  7. Andreas Markus Hoetker
    22 Hoetker