Whole-brain radiotherapy in patients with brain metastases from melanoma Journal Article
| Authors: | De La Fuente, M.; Beal, K.; Carvajal, R.; Kaley, T. J. |
| Article Title: | Whole-brain radiotherapy in patients with brain metastases from melanoma |
| Abstract: | AIMS: To describe results of melanoma brain metastases (BM) treated with whole-brain radiation (WBRT). METHODS: Retrospective review of patients with melanoma BM treated with WBRT divided into two groups based on the timing of WBRT (at BM diagnosis or recurrence). RESULTS: We identified 61 patients with melanoma BM who received WBRT. For the group treated at diagnosis (n = 39): median overall survival was 3 months; best radiographic response included one partial response, ten stable disease, 18 progressive disease, and ten no follow-up imaging. For the group treated at recurrence (n = 22): median overall survival was 3 months; best radiographic response was three partial response, four stable disease, eight progressive disease, and seven no follow-up imaging. CONCLUSION: WBRT activity was limited; however, its role in symptom palliation is unclear. |
| Keywords: | adult; treatment outcome; aged; aged, 80 and over; middle aged; retrospective studies; young adult; overall survival; mortality; brain neoplasms; ipilimumab; melanoma; retrospective study; skull irradiation; cranial irradiation; kaplan meier method; brain metastases; kaplan-meier estimate; secondary; procedures; radiographic response; very elderly; humans; human; male; female; wbrt |
| Journal Title: | CNS Oncology |
| Volume: | 3 |
| Issue: | 6 |
| ISSN: | 2045-0907 |
| Publisher: | Future Medicine |
| Date Published: | 2014-01-01 |
| Start Page: | 401 |
| End Page: | 406 |
| Language: | English |
| DOI: | 10.2217/cns.14.40 |
| PUBMED: | 25438811 |
| PROVIDER: | scopus |
| PMCID: | PMC6113948 |
| DOI/URL: | |
| Notes: | Export Date: 2 September 2015 -- Source: Scopus |
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