Cellular and molecular mechanisms of lymphangiogenesis and lymphedema Journal Article

Authors: Avraham, T.; Quartaro, P. J.; Daluvoy, S. V.; Mehrara, B. J.
Article Title: Cellular and molecular mechanisms of lymphangiogenesis and lymphedema
Abstract: Chronic secondary lymphedema is a potentially devastating condition affecting 90-150 million people worldwide. In the US, lymphedema is most commonly encountered in the upper extremity of women who have undergone axillary lymph node dissection for staging and treatment of breast cancer, though it may also occur following lymph node dissection for melanoma as well as certain gynecology oncologic operations. While a great deal has been elucidated about the biology of lymphatics, lymphatic development, and the lymphatic system in the past 20 years, considerably less is known about impaired lymphatic regeneration and the mechanisms that lead to secondary lymphedema. This deficit in knowledge presents a barrier to the development of effective treatments or prophylactic measures for chronic secondary lymphedema. Recent advances in this arena have showed that pathogenesis of lymphedema is complex, and that effective treatments for this often devastating condition will likely require the use of multiple modalities. In this review, we will discuss the development, anatomy, and physiology of lymphatics as means of introducing this system to the reader. Further, the latest advances in the scientific exploration of lymphedema and lymphatic regeneration will be presented. © 2009 Bentham Science Publishers Ltd.
Keywords: vasculotropin receptor 3; pathogenesis; review; nonhuman; cancer staging; lymph node dissection; lymphoscintigraphy; melanoma; breast cancer; risk factor; physiology; vasculotropin c; lymphangiogenesis; lymphedema; lymphatic regeneration; wound; fibroblast growth factor 2; molecular marker; podoplanin; scatter factor; vasculotropin d; axillary lymph node; chronic disease; disease model; imaging system; lymphatic system; molecular mechanics; pathological anatomy
Journal Title: Current Cancer Therapy Reviews
Volume: 5
Issue: 1
ISSN: 1573-3947
Publisher: Bentham Science Publishers  
Date Published: 2009-02-01
Start Page: 28
End Page: 36
Language: English
DOI: 10.2174/157339409787314063
PROVIDER: scopus
Notes: --- - "Export Date: 30 November 2010" - "Source: Scopus"
Citation Impact
MSK Authors
  1. Sanjay Daluvoy
    17 Daluvoy
  2. Babak Mehrara
    289 Mehrara
  3. Tomer Avraham
    33 Avraham