Radioiodine ablation of thyroid remnants after preparation with recombinant human thyrotropin Journal Article
| Authors: | Robbins, R. J.; Tuttle, R. M.; Sonenberg, M.; Shaha, A.; Sharaf, R.; Robbins, H.; Fleisher, M.; Larson, S. M. |
| Article Title: | Radioiodine ablation of thyroid remnants after preparation with recombinant human thyrotropin |
| Abstract: | Radioiodine ablation (RA) of normal thyroid remnants after thyroidectomy for differentiated thyroid carcinoma improves the sensitivity of subsequent radioiodine scans and serum thyroglobulin measurements for detection of residual thyroid carcinoma. Local cancer recurrences are also lower after RA. One standard preparation for RA involves rendering the patient hypothyroid in order to stimulate endogenous thyrotropin (TSH) secretion and sodium iodide symporter (NIS) activity. An alternative approach is to prescribe thyroxine after thyroidectomy and to stimulate NIS with exogenous recombinant human thyrotropin (rhTSH). This latter approach was used in 10 patients at our medical center. Complete resolution of all visible 131I thyroid bed uptake was achieved in all when follow-up scans were performed 5 to 13 months later. This approach has the potential to successfully ablate thyroid remnants without the need to induce hypothyroidism. |
| Keywords: | adult; clinical article; aged; middle aged; unclassified drug; cancer recurrence; treatment planning; conference paper; cancer radiotherapy; postoperative care; follow up; carcinoma, papillary; gene product; iodine 131; radioactive iodine; iodine radioisotopes; minimal residual disease; recombinant proteins; carcinoma; gamma cameras; thyroidectomy; thyroid carcinoma; thyroid neoplasms; hypothyroidism; thyroglobulin; thyroglobulin blood level; thyroid gland; recombinant thyrotropin; thyrotropin; sodium iodide symporter; thyroid scintiscanning; sodium iodide; humans; human; male; female; priority journal; thyrotropin release |
| Journal Title: | Thyroid |
| Volume: | 11 |
| Issue: | 9 |
| ISSN: | 1050-7256 |
| Publisher: | Mary Ann Liebert, Inc |
| Date Published: | 2001-09-01 |
| Start Page: | 865 |
| End Page: | 869 |
| Language: | English |
| PUBMED: | 11575856 |
| PROVIDER: | scopus |
| DOI: | 10.1089/105072501316973127 |
| DOI/URL: | |
| Notes: | Export Date: 21 May 2015 -- Source: Scopus |
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