Laparoscopy and laparoscopic ultrasonography in gastric cancer: A new look at an old problem Journal Article

  


Author: Karpeh, M. S. Jr
Article Title: Laparoscopy and laparoscopic ultrasonography in gastric cancer: A new look at an old problem
Abstract: Gastric cancer remains a leading cause of cancer deaths worldwide. Surgical resection is required for potential long-term cure; however, 5-year survival remains poor unless the disease is confined to the superficial layers. Studies demonstrate failure to be most commonly locoregional relapse. Adjuvant therapy, therefore, has a potentially important role in the treatment of patients with resectable gastric cancer. Recently, attention has been focused on neoadjuvant therapy with it concomitant theoretical advantages. A neoadjuvant strategy may offer the patient significant benefit by exposing micrometastases to chemotherapy early and, thereby, enhancing resectability due to chemoradiation-induced tumor down-staging. Furthermore, neoadjuvant therapy would provide a means to assess both clinical and pathologic responses to determine potential benefits of additional treatment after surgical resection. In addition, a neoadjuvant strategy would provide a means to identify patients with rapid disease progression and, therefore, would not benefit from a gastric resection. New studies have determined that preoperative chemotherapy for potentially resectable gastric cancer results in a high rate of tumor downstaging, and response to preoperative chemotherapy best predicts survival. Clinical trials are underway to determine the efficacy of neoadjuvant therapy on overall survival in gastric cancer.
Keywords: cancer surgery; advanced cancer; treatment planning; conference paper; cancer staging; cancer diagnosis; laparoscopy; diagnostic procedure; metastasis; cancer screening; diagnostic imaging; echography; gastrectomy; stomach cancer; human
Journal Title: Asian Journal of Surgery
Volume: 24
Issue: 3
ISSN: 1015-9584
Publisher: Elsevier Inc.  
Date Published: 2001-07-01
Start Page: 242
End Page: 247
Language: English
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-0034852671&partnerID=40&md5=4318462a5146d702ec97e69bdc33a90f
Notes: Export Date: 21 May 2015 -- Source: Scopus