Results of hepatic resection for sarcoma metastatic to liver Journal Article
| Authors: | DeMatteo, R. P.; Shah, A.; Fong, Y.; Jarnagin, W. R.; Blumgart, L. H.; Brennan, M. F. |
| Article Title: | Results of hepatic resection for sarcoma metastatic to liver |
| Abstract: | Objective: To evaluate the outcome of patients with liver metastases from sarcoma who underwent hepatic resection at a single institution and were followed up prospectively. Summary Background Data: The value of hepatic resection for metastatic sarcoma is unknown. Methods: There were 331 patients with liver metastases from sarcoma who were admitted to Memorial Hospital from 1982 to 2000, and 56 of them underwent resection of all gross hepatic disease. Patient, tumor, and treatment variables were analyzed to assess outcome. Results: Of the 56 patients who underwent complete resection, 34 (61%) had gastrointestinal stromal tumors or gastrointestinal leiomyosarcomas. Half of the patients required an hepatic lobectomy or extended lobectomy. There were no perioperative deaths in the completely resected group, although 3 of the 75 patients who underwent exploration (4%) died. The postoperative 1-, 3-, and 5-year actuarial survival rates were 88%, 50%, and 30%, respectively, with a median of 39 months. In contrast, the 5-year survival rate of patients who did not undergo complete resection was 4%. On multivariate analysis, a time interval from the primary tumor to the development of liver metastasis greater than 2 years was a significant predictor of survival after hepatectomy. Conclusions: Complete resection of liver metastases from sarcoma in selected patients is associated with prolonged survival. Hepatectomy should be considered when complete gross resection is possible, especially when the time to the development of liver metastasis exceeds 2 years. |
| Keywords: | adolescent; adult; cancer survival; treatment outcome; aged; middle aged; survival analysis; surgical technique; survival rate; retrospective studies; major clinical study; risk benefit analysis; liver neoplasms; conference paper; follow up; follow-up studies; treatment indication; proportional hazards models; prediction; sarcoma; liver metastasis; probability; stroma; liver resection; liver disease; hepatectomy; multivariate analysis; leiomyosarcoma; soft tissue neoplasms; humans; human; male; female; priority journal |
| Journal Title: | Annals of Surgery |
| Volume: | 234 |
| Issue: | 4 |
| ISSN: | 0003-4932 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2001-10-01 |
| Start Page: | 540 |
| End Page: | 548 |
| Language: | English |
| DOI: | 10.1097/00000658-200110000-00013 |
| PUBMED: | 11573047 |
| PROVIDER: | scopus |
| PMCID: | PMC1422077 |
| DOI/URL: | |
| Notes: | Presented at 121st Annual Scietific Session of the American Surgical Association -- 2001 Apr 26-28 -- Colorado Springs, CO -- Export Date: 21 May 2015 -- Source: Scopus |
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