Prospective randomized clinical trial of the value of intraperitoneal drainage after pancreatic resection Journal Article
| Authors: | Conlon, K. C.; Labow, D.; Leung, D.; Smith, A.; Jarnagin, W.; Coit, D. G.; Merchant, N.; Brennan, M. F. |
| Article Title: | Prospective randomized clinical trial of the value of intraperitoneal drainage after pancreatic resection |
| Abstract: | Objective: To test the hypothesis that routine intraperitoneal drainage is not required after pancreatic resection. Summary Background Data: The use of surgically placed intraperitoneal drains has been considered routine after pancreatic resection. Recent studies have suggested that for other major upper abdominal resections, routine postoperative drainage is not required and may be associated with an increased complication rate. Methods: After informed consent, eligible patients with peripancreatic tumors were randomized during surgery either to have no drains placed or to have closed suction drainage placed in a standardized fashion after pancreatic resection. Clinical, pathologic, and surgical details were recorded. Results: One hundred seventy-nine patients were enrolled in the study, 90 women and 89 men. Mean age was 65.4 years (range 23-87). The pancreas was the tumor site in 142 (79%) patients, with the ampulla (n=24), duodenum (n=10), and distal common bile duct (n=3) accounting for the remainder. A pancreaticoduodenectomy was performed in 139 patients and a distal pancreatectomy in 40 cases. Eighty-eight patients were randomized to have drains placed. Demographic, surgical, and pathologic details were similar between both groups. The overall 30-day death rate was 2% (n=4). A postoperative complication occurred during the initial admission in 107 patients (59%). There was no significant difference in the number or type of complications between groups. In the drained group, 11 patients (12.5%) developed a pancreatic fistula. Patients with a drain were more likely to develop a significant intraabdominal abscess, collection, or fistula. Conclusion: This randomized prospective clinical trial failed to show a reduction in the number of deaths or complications with the addition of surgical intraperitoneal closed suction drainage after pancreatic resection. The data suggest that the presence of drains failed to reduce either the need for interventional radiologic drainage or surgical exploration for intraabdominal sepsis. Based on these results, closed suction drainage should not be considered mandatory or standard after pancreatic resection. |
| Keywords: | adult; controlled study; human tissue; treatment outcome; aged; aged, 80 and over; middle aged; survival analysis; surgical technique; major clinical study; clinical trial; mortality; postoperative period; risk benefit analysis; conference paper; pancreas resection; postoperative care; pancreatic neoplasms; follow-up studies; sensitivity and specificity; prospective studies; pancreaticoduodenectomy; controlled clinical trial; randomized controlled trial; abdominal abscess; prevalence; postoperative complication; postoperative complications; standardization; probability; reference values; pancreatectomy; sepsis; abdominal drainage; drainage; infection complication; pancreas fistula; peritoneal cavity; suction drainage; humans; human; male; female; priority journal |
| Journal Title: | Annals of Surgery |
| Volume: | 234 |
| Issue: | 4 |
| ISSN: | 0003-4932 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2001-10-01 |
| Start Page: | 487 |
| End Page: | 494 |
| Language: | English |
| DOI: | 10.1097/00000658-200110000-00008 |
| PUBMED: | 11573042 |
| PROVIDER: | scopus |
| PMCID: | PMC1422072 |
| DOI/URL: | |
| Notes: | Presented at 121st Annual Scietific Session of the American Surgical Association; 2001 Apr 26-28; Colorado Springs, CO -- Export Date: 21 May 2015 -- Source: Scopus |
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