Modeling the effects of inhomogeneous dose distributions in normal tissues Journal Article
| Authors: | Yorke, E. D.; Ellen, D. |
| Article Title: | Modeling the effects of inhomogeneous dose distributions in normal tissues |
| Abstract: | Conformal radiation therapy frequently produces inhomogeneous dose distributions in normal tissues near the target. Most mathematical models of normal tissue complication probabilities (NTCP) are based on uniform whole or partial organ irradiation, and the model parameters are chosen to obtain agreement with clinical outcomes in these simple situations. Frequently used NTCP models and methods for including inhomogeneous dose distributions in model calculations are outlined in this report. It has been found that the model adopted may qualitatively affect prediction of complications. Limitations placed on current models by the scarcity of reliable complications data and other approaches to using the calculated dose distribution to predict NTCP are discussed. Copyright © 2001 by W.B. Saunders Company. |
| Keywords: | review; models, biological; radiation injury; dose-response relationship, radiation; mathematical model; tissue distribution; radiation dose fractionation; probability; reference values; computer assisted radiotherapy; radiation dose distribution; tissue reaction; humans; priority journal |
| Journal Title: | Seminars in Radiation Oncology |
| Volume: | 11 |
| Issue: | 3 |
| ISSN: | 1053-4296 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2001-01-01 |
| Start Page: | 197 |
| End Page: | 209 |
| Language: | English |
| PUBMED: | 11447576 |
| PROVIDER: | scopus |
| DOI: | 10.1053/srao.2001.23478 |
| DOI/URL: | |
| Notes: | Export Date: 21 May 2015 -- Source: Scopus |
