Monoclonal antibody-based therapy of neuroblastoma Journal Article
| Authors: | Cheung, N. K. V.; Kushner, B. H.; Kramer, K. |
| Article Title: | Monoclonal antibody-based therapy of neuroblastoma |
| Abstract: | The curative potential of mAbs in the treatment of patients with metastatic neuroblastoma is increasingly evident. The idiotype network appears to represent one component of a complex mechanism for success with mAb-based immunotherapy. Ongoing strategies to modify or reconstruct mAbs, to engage them with cytokines, or to unite them with T cells open new avenues for harnessing the unique forces of the immune system against some of the most deadly pediatric cancers. |
| Keywords: | signal transduction; cancer chemotherapy; cancer survival; child; treatment outcome; unclassified drug; clinical trial; drug tolerability; review; doxorubicin; cancer radiotherapy; radiation dose; cancer staging; interleukin 2; cancer immunotherapy; immune system; etoposide; neuropathy; granulocyte macrophage colony stimulating factor; cyclophosphamide; vincristine; protein interaction; childhood cancer; monoclonal antibody; fever; hypotension; cancer regression; antibodies, monoclonal; immunotherapy; neuroblastoma; radiopharmaceutical agent; nausea and vomiting; drug half life; radioimmunotherapy; clinical trials; monoclonal antibody 3f8; monoclonal antibody 3f8 i 131; antigen antibody complex; chimeric antibody; antibodies, anti-idiotypic; immunotherapy, active; humans; human; priority journal; chimeric antibody ch 14.18; monoclonal antibody 14 g2a; monoclonal antibody i 131 |
| Journal Title: | Hematology/Oncology Clinics of North America |
| Volume: | 15 |
| Issue: | 5 |
| ISSN: | 0889-8588 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2001-10-01 |
| Start Page: | 853 |
| End Page: | 864 |
| Language: | English |
| PUBMED: | 11765377 |
| PROVIDER: | scopus |
| DOI: | 10.1016/s0889-8588(05)70255-0 |
| DOI/URL: | |
| Notes: | Export Date: 21 May 2015 -- Source: Scopus |
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