Mitotic checkpoints: From yeast to cancer Journal Article
| Authors: | Wassmann, K.; Benezra, R. |
| Article Title: | Mitotic checkpoints: From yeast to cancer |
| Abstract: | Separation of chromosomes during mitosis is monitored by a checkpoint that leads to cell-cycle arrest if the chromosomes are not properly attached to the mitotic spindle. Molecular mechanisms controlling this checkpoint have been identified. In addition, loss of this checkpoint has been shown to result in chromosome missegregation in higher eukaryotes and may contribute to the genomic instability observed in human cancers. |
| Keywords: | signal transduction; protein phosphorylation; review; nonhuman; neoplasms; mitosis; animals; cell cycle; eukaryota; genetic stability; anaphase; mitotic spindle apparatus; mitosis rate; eukaryotic cell; aneuploidy; cell activity; adenomatous polyposis coli protein; phosphoprotein; yeast cell; metaphase; genes, cdc; centromere; chromosome segregation; cytoskeletal proteins; yeasts; kinetochores; mitosis inhibition; humans; priority journal |
| Journal Title: | Current Opinion in Genetics and Development |
| Volume: | 11 |
| Issue: | 1 |
| ISSN: | 0959-437X |
| Publisher: | Elsevier Inc. |
| Date Published: | 2001-02-01 |
| Start Page: | 83 |
| End Page: | 90 |
| Language: | English |
| DOI: | 10.1016/s0959-437x(00)00161-1 |
| PUBMED: | 11163156 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 21 May 2015 -- Source: Scopus |
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