Stereotactic core-needle breast biopsy: A multi-institutional prospective trial Journal Article


Authors: Brenner, R. J.; Bassett, L. W.; Fajardo, L. L.; Dershaw, D. D.; Evans, W. P.; Hunt, R.; Lee, C.; Tocino, I.; Fisher, P.; McCombs, M.; Jackson, V. P.; Feig, S. A.; Mendelson, E. B.; Margolin, F. R.; Bird, R.; Sayre, J.
Article Title: Stereotactic core-needle breast biopsy: A multi-institutional prospective trial
Abstract: PURPOSE: To assess the accuracy of stereotactic core-needle biopsy (CNB) of nonpalpable breast lesions within the context of clinically important parameters of anticipated tissue-sampling error and concordance with mammographic findings. MATERIALS AND METHODS: CNB was performed in 1,003 patients, with results validated at surgery or clinical and mammographic follow-up. Mammographic findings were scored according to the American College of Radiology Breast Imaging Reporting and Data System with a similar correlative scale for histopathologic samples obtained at either CNB or surgery. Agreement of CNB findings with surgical findings or evidence of no change during clinical and mammographic follow-up (median, 24 months) for benign lesions was used to determine results. Three forms of diagnostic discrimination measures (strict, working [strict conditioned by tissue sampling error], applied [working conditioned by concordance of imaging and CNB findings) were used to evaluate the correlation of CNB, surgical, and follow-up results. RESULTS: Strict, working, and applied sensitivities were 91% +/- 1.9; 92% +/- 1.8, and 98% +/- 0.9, respectively; strict, working, and applied specificities were 100%, 98% +/- 0.8, and 73% +/- 0.9; strict, working, and applied accuracies were 97%, 96%, and 79%. CONCLUSION: Percutaneous stereotactic CNB is an accurate method to establish a histopathologic diagnosis of nonpalpable breast lesions. Accuracy increases when additional surgery is performed for lesions with anticipated sampling error or when CNB findings are discordant with mammographic findings. An understanding of the interrelationship among these parameters is necessary to properly assess results.
Keywords: accuracy; diagnosis; cost-effectiveness; follow-up; utilization; screening mammography; atypical ductal hyperplasia; aspiration cytology; mammographic; probably benign lesions; surgical biopsy; breast neoplasms, diagnosis; breast, biopsy; breast radiography,; detected abnormalities
Journal Title: Radiology
Volume: 218
Issue: 3
ISSN: 0033-8419
Publisher: Radiological Society of North America, Inc.  
Date Published: 2001-03-01
Start Page: 866
End Page: 872
Language: English
ACCESSION: WOS:000167138400037
PROVIDER: wos
PUBMED: 11230668
DOI: 10.1148/radiology.218.3.r01mr44866
Notes: Article -- Source: Wos
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  1. D David Dershaw
    223 Dershaw