La cyclooxygenase-2: Nouvelle cible dans le traitement des cancers epitheliaux - Les cyclooxygenases Journal Article
| Authors: | Eschwege, P.; de Ledinghen, V.; Camilli, T.; Kulkarni, S.; Dalbagni, G.; Droupy, S.; Jardin, A.; Benoit, G.; Weksler, B. B. |
| Article Title: | La cyclooxygenase-2: Nouvelle cible dans le traitement des cancers epitheliaux - Les cyclooxygenases |
| Abstract: | Two isoforms: There are two isoforms of cyclooxygenase (COX) with similar structure and metabolic activity. COX-1 is a constitutional enzyme. COX-2 is an inductible form. Cyclooxygenase-1: COX-1 is present in most tissues, particularly in the kidney, the digestive tract mucosa, platelets, brain, liver and spleen. Cyclooxygenase-2: COX-2 expression can be induced by an inflammatory process. Implicated in the development of certain cancers, COX-2 is expressed in numerous tumor cell lines and in most epithelial carcinomas. COX-2 favors tumor invasion and inhibits apoptosis. When it is absent tumor growth is slower or stopped. (C) 2001, Masson, Paris. |
| Keywords: | carcinoma; phorbol ester; gene-expression; squamous-cell; endothelial-cells; inhibition; adenocarcinomas; synthetase; human colon-cancer; arachidonic-acid; prostaglandin endoperoxide synthase |
| Journal Title: | Presse Medicale |
| Volume: | 30 |
| Issue: | 10 |
| ISSN: | 0755-4982 |
| Publisher: | Masson Editeur |
| Date Published: | 2001-03-17 |
| Start Page: | 511 |
| End Page: | 514 |
| Language: | French |
| ACCESSION: | WOS:000167713200013 |
| PROVIDER: | wos |
| Notes: | [Cyclooxygenase-2: a new target for epithelial cancer treatments - Cyclooxygenases] -- Article -- Source: Wos |
