Therapy of chemotherapy-induced peripheral neuropathy Journal Article

  


Authors: Kaley, T. J.; Deangelis, L. M.
Article Title: Therapy of chemotherapy-induced peripheral neuropathy
Abstract: Chemotherapy-induced peripheral neuropathy (CIPN) is still a common and disabling side effect of many chemotherapy agents in use today. Unfortunately, neither prophylactic strategies nor symptomatic treatments have proven useful yet. This review will discuss the diagnosis and evaluation of neuropathy in cancer patients, as well as reviewing the various prophylactic and symptomatic treatments that have been proposed or tried. However, sufficient evidence is lacking to recommend any of these treatments to patients suffering with CIPN. Therefore, the best approach is to treat symptomatically, and to start with broad-spectrum analgesic medications such as non-steroidal anti-inflammatory drugs (NSAIDs). If NSAIDs fail, a reasonable second-line agent in properly selected patients may be an opioid. Unfortunately, even when effective in other types of neuropathic pain, anti-depressants and anticonvulsants have not yet proven effective for treating the symptoms of CIPN. © 2009 Blackwell Publishing Ltd.
Keywords: cancer chemotherapy; fludarabine; thalidomide; clinical trial; cisplatin; placebo; cancer combination chemotherapy; disease classification; drug withdrawal; nonhuman; antineoplastic agents; paclitaxel; cancer patient; chemotherapy; cytarabine; neurotoxicity; antineoplastic agent; neoplasms; unindexed drug; bortezomib; multiple cycle treatment; multiple myeloma; sensory neuropathy; etoposide; peripheral neuropathy; combination chemotherapy; cyclophosphamide; vincristine; procarbazine; docetaxel; hypotension; nonsteroid antiinflammatory agent; anti-inflammatory agents, non-steroidal; prophylaxis; clinical evaluation; vitamin supplementation; altretamine; platinum derivative; alpha tocopherol; acupuncture; vinca alkaloid; physical examination; misonidazole; taxane derivative; analgesics, opioid; anesthetics, local; oxaliplatin; neuropathic pain; autonomic neuropathy; chemotherapy-induced peripheral neuropathy; neuropathy treatment; amifostine; azacitidine; gluconate calcium; glutathione; magnesium sulfate; mitotane; suramin; teniposide; cranial neuropathy; diabetic neuropathy; drug induced disease; sensorimotor neuropathy; anticonvulsants; antidepressive agents, tricyclic; peripheral nervous system diseases
Journal Title: British Journal of Haematology
Volume: 145
Issue: 1
ISSN: 0007-1048
Publisher: John Wiley & Sons  
Date Published: 2009-04-01
Start Page: 3
End Page: 14
Language: English
DOI: 10.1111/j.1365-2141.2008.07558.x
PUBMED: 19170681
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-61849097298&partnerID=40&md5=1370ccd34ec20b349a9da785b4ea066d
Notes: --- - "Cited By (since 1996): 12" - "Export Date: 30 November 2010" - "CODEN: BJHEA" - "Source: Scopus"
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MSK Authors
  1. Lisa De Angelis
    576 De Angelis
  2. Thomas Kaley
    154 Kaley
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