Prediction of breast cancer risk based on profiling with common genetic variants Journal Article

   


Authors: Mavaddat, N.; Pharoah, P. D. P.; Michailidou, K.; Tyrer, J.; Brook, M. N.; Bolla, M. K.; Wang, Q.; Dennis, J.; Dunning, A. M.; Shah, M.; Luben, R.; Brown, J.; Bojesen, S. E.; Nordestgaard, B. G.; Nielsen, S. F.; Flyger, H.; Czene, K.; Darabi, H.; Eirksson, M.; Peto, J.; dos-Santos-Silva, I.; Dudbridge, F.; Johnson, N.; Schmidt, M. K.; Broeks, A.; Verhoef, S.; Rutgers, E. J.; Swerdlow, A.; Ashworth, A.; Orr, N.; Schoemaker, M. J.; Figueroa, J.; Chanock, S. J.; Brinton, L.; Lissowska, J.; Couch, F. J.; Olson, J. E.; Vachon, C.; Pankratz, V. S.; Lambrechts, D.; Wildiers, H.; Van Ongeval, C.; Van Limbergen, E.; Kristensen, V.; Alnaes, G. G.; Nord, S.; Borresen-Dale, A. L.; Nevanlinna, H.; Muranen, T. A.; Aittomaki, K.; Blomqvist, C.; Chang-Claude, J.; Rudolph, A.; Seibold, P.; Flesch-Janys, D.; Fasching, P. A.; Haeberle, L.; Ekici, A. B.; Beckmann, M. W.; Burwinkel, B.; Marme, F.; Schneeweiss, A.; Sohn, C.; Trentham-Dietz, A.; Newcomb, P.; Titus, L.; Egan, K. M.; Hunter, D. J.; Lindstrom, S.; Tamimi, R. M.; Kraft, P.; Rahman, N.; Turnbull, C.; Renwick, A.; Seal, S.; Li, J.; Liu, J.; Humphreys, K.; Benitez, J.; Zamora, M. P.; Ignacio, J.; Perez, A.; Menendez, P.; Jakubowska, A.; Lubinski, J.; Jaworska-Bieniek, K.; Durda, K.; Bogdanova, N. V.; Antonenkova, N. N.; Dork, T.; Anton-Culver, H.; Neuhausen, S. L.; Ziogas, A.; Bernstein, L.; Devilee, P.; Tollenaar, R. A. E. M.; Seynaeve, C.; van Asperen, C. J.; Cox, A.; Cross, S. S.; Reed, M. W. R.; Khusnutdinova, E.; Bermisheva, M.; Prokofyeva, D.; Takhirova, Z.; Meindl, A.; Schmutzler, R. K.; Sutter, C.; Yang, R.; Schurmann, P.; Bremer, M.; Christiansen, H.; Park-Simon, T. W.; Hillemanns, P.; Guenel, P.; Truong, T.; Menegaux, F.; Sanchez, M.; Radice, P.; Peterlongo, P.; Manoukian, S.; Pensotti, V.; Hopper, J. L.; Tsimiklis, H.; Apicella, C.; Southey, M. C.; Brauch, H.; Bruning, T.; Ko, Y. D.; Sigurdson, A. J.; Doody, M. M.; Hamann, U.; Torres, D.; Ulmer, H. U.; Forsti, A.; Sawyer, E. J.; Tomlinson, I.; Kerin, M. J.; Miller, N.; Andrulis, I. L.; Knight, J. A.; Glendon, G.; Mulligan, A. M.; Chenevix-Trench, G.; Balleine, R.; Giles, G. G.; Milne, R. L.; McLean, C.; Lindblom, A.; Margolin, S.; Haiman, C. A.; Henderson, B. E.; Schumacher, F.; Le Marchand, L.; Eilber, U.; Wang-Gohrke, S.; Hooning, M. J.; Hollestelle, A.; van den Ouweland, A. M. W.; Koppert, L. B.; Carpenter, J.; Clarke, C.; Scott, R.; Mannermaa, A.; Kataja, V.; Kosma, V. M.; Hartikainen, J. M.; Brenner, H.; Arndt, V.; Stegmaier, C.; Dieffenbach, A. K.; Winqvist, R.; Pylkas, K.; Jukkola-Vuorinen, A.; Grip, M.; Offit, K.; Vijai, J.; Robson, M.; Rau-Murthy, R.; Dwek, M.; Swann, R.; Perkins, K. A.; Goldberg, M. S.; Labreche, F.; Dumont, M.; Eccles, D. M.; Trapper, W. J.; Rafiq, S.; John, E. M.; Whittemore, A. S.; Slager, S.; Yannoukakos, D.; Toland, A. E.; Yao, S.; Zheng, W.; Halverson, S. L.; Gonzalez-Neira, A.; Pita, G.; Alonso, M. R.; Alvarez, N.; Herrero, D.; Tessier, D. C.; Vincent, D.; Bacot, F.; Luccarini, C.; Baynes, C.; Ahmed, S.; Matanian, M.; Healey, C. S.; Simard, J.; Hall, P.; Easton, D. F.; Garcia-Closas, M.
Article Title: Prediction of breast cancer risk based on profiling with common genetic variants
Abstract: Background: Data for multiple common susceptibility alleles for breast cancer may be combined to identify women at different levels of breast cancer risk. Such stratification could guide preventive and screening strategies. However, empirical evidence for genetic risk stratification is lacking. Methods: We investigated the value of using 77 breast cancer-associated single nucleotide polymorphisms (SNPs) for risk stratification, in a study of 33 673 breast cancer cases and 33 381 control women of European origin. We tested all possible pair-wise multiplicative interactions and constructed a 77-SNP polygenic risk score (PRS) for breast cancer overall and by estrogen receptor (ER) status. Absolute risks of breast cancer by PRS were derived from relative risk estimates and UK incidence and mortality rates. Results: There was no strong evidence for departure from a multiplicative model for any SNP pair. Women in the highest 1% of the PRS had a three-fold increased risk of developing breast cancer compared with women in the middle quintile (odds ratio [OR] = 3.36, 95% confidence interval [CI] = 2.95 to 3.83). The ORs for ER-positive and ER-negative disease were 3.73 (95% CI = 3.24 to 4.30) and 2.80 (95% CI = 2.26 to 3.46), respectively. Lifetime risk of breast cancer for women in the lowest and highest quintiles of the PRS were 5.2% and 16.6% for a woman without family history, and 8.6% and 24.4% for a woman with a first-degree family history of breast cancer. Conclusions: The PRS stratifies breast cancer risk in women both with and without a family history of breast cancer. The observed level of risk discrimination could inform targeted screening and prevention strategies. Further discrimination may be achievable through combining the PRS with lifestyle/environmental factors, although these were not considered in this report.
Keywords: prostate; women; genome-wide association; prevention; susceptibility loci; consortium; subtypes; family-history
Journal Title: JNCI: Journal of the National Cancer Institute
Volume: 107
Issue: 5
ISSN: 0027-8874
Publisher: Oxford University Press  
Date Published: 2015-05-01
Start Page: djv036
Language: English
ACCESSION: WOS:000355088600009
DOI: 10.1093/jnci/djv036
PROVIDER: wos
PUBMED: 25855707
PMCID: PMC4754625
Notes: Article -- djv036 -- Source: Wos
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MSK Authors
  1. Kenneth Offit
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  2. Mark E Robson
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  3. Vijai Joseph
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  4. Rohini Subhadra Rau Murthy
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