Low-grade sinonasal adenocarcinomas: The association with and distinction from respiratory epithelial adenomatoid hamartomas and other glandular lesions Journal Article
| Authors: | Jo, V. Y.; Mills, S. E.; Cathro, H. P.; Carlson, D. L.; Stelow, E. B. |
| Article Title: | Low-grade sinonasal adenocarcinomas: The association with and distinction from respiratory epithelial adenomatoid hamartomas and other glandular lesions |
| Abstract: | Sinonasal adenocarcinomas (SNACs) are uncommon malignancies that show a variety of growth patterns. These lesions are classified as intestinal or nonintestinal, the latter subclassified as low grade or high grade. We have noted that some low-grade nonintestinal SNACs are associated with respiratory epithelial adenomatoid hamartomas (REAHs), also rare lesions that have recently been shown to be neoplastic. We reviewed 29 nonintestinal low-grade SNACs seen at our institution over a 20-year period, with particular attention to morphology and concomitant REAHs. Nine (31%) low-grade SNACs demonstrated a predominantly exophytic and papillary growth pattern, and 18 (72%) had a more tubular growth pattern. Two (7%) were categorized as "other." Six low-grade tubular SNACs were associated with REAHs. An immunohistochemical panel was performed on 2 of these cases; neoplastic cells were immunoreactive with antibodies to CK7 and S100 protein and nonreactive with antibodies to CK20, similar to other low-grade SNACs. No basal cells or myoepithelial differentiation was seen with immunohistochemical stains for p63 and 34βE12. This association of low-grade tubular SNACs with REAHs suggests that REAHs may be related to some adenocarcinomas. © 2009 Lippincott Williams & Wilkins. |
| Keywords: | immunohistochemistry; controlled study; human tissue; major clinical study; cancer grading; adenocarcinoma; metabolism; diagnosis, differential; differential diagnosis; cell differentiation; pathology; immunoreactivity; basal cell; adenoma; protein s 100; cytokeratin 20; protein p63; cytokeratin 7; low grade; respiratory epithelial adenomatoid hamartoma; sinonasal; hamartoma; nose carcinoma; sinoasal adenocarcinoma; nose tumor; paranasal sinus; respiratory tract mucosa; nose neoplasms; paranasal sinuses; respiratory mucosa |
| Journal Title: | American Journal of Surgical Pathology |
| Volume: | 33 |
| Issue: | 3 |
| ISSN: | 0147-5185 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2009-03-01 |
| Start Page: | 401 |
| End Page: | 408 |
| Language: | English |
| DOI: | 10.1097/PAS.0b013e3181874ee8 |
| PUBMED: | 19011560 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 6" - "Export Date: 30 November 2010" - "CODEN: AJSPD" - "Source: Scopus" |
