Radioimmunotherapy of human tumours Journal Article

   


Authors: Larson, S. M.; Carrasquillo, J. A.; Cheung, N. K. V.; Press, O. W.
Article Title: Radioimmunotherapy of human tumours
Abstract: The eradication of cancer remains a vexing problem despite recent advances in our understanding of the molecular basis of neoplasia. One therapeutic approach that has demonstrated potential involves the selective targeting of radionuclides to cancer-associated cell surface antigens using monoclonal antibodies. Such radioimmunotherapy (RIT) permits the delivery of a high dose of therapeutic radiation to cancer cells, while minimizing the exposure of normal cells. Although this approach has been investigated for several decades, the cumulative advances in cancer biology, antibody engineering and radiochemistry in the past decade have markedly enhanced the ability of RIT to produce durable remissions of multiple cancer types. © 2015 Macmillan Publishers Limited. All rights reserved.
Keywords: review; nonhuman; solid tumor; drug targeting; cancer radiotherapy; radiation dose; cancer immunotherapy; hematopoietic stem cell transplantation; immunoreactivity; tumor antigen; acute lymphoblastic leukemia; monoclonal antibody; cancer regression; membrane antigen; hematologic malignancy; dosimetry; cancer cell; lymphoma; radioisotope; radioimmunotherapy; multiple cancer; follicular lymphoma; radiochemistry; antibody engineering; clinical trial (topic); phase 2 clinical trial (topic); phase 3 clinical trial (topic); antigen antibody complex; bispecific antibody; human; priority journal
Journal Title: Nature Reviews Cancer
Volume: 15
Issue: 6
ISSN: 1474-175X
Publisher: Nature Publishing Group  
Date Published: 2015-06-01
Start Page: 347
End Page: 360
Language: English
DOI: 10.1038/nrc3925
PROVIDER: scopus
PUBMED: 25998714
PMCID: PMC4798425
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-84929910660&partnerID=40&md5=bf01ba7237f2b5b4b0b2c2ffe338843d
Notes: Export Date: 2 July 2015 -- Source: Scopus
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MSK Authors
  1. Nai-Kong Cheung
    648 Cheung
  2. Jorge Carrasquillo
    140 Carrasquillo
  3. Steven M Larson
    958 Larson
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