Carotid sparing intensity-modulated radiation therapy achieves comparable locoregional control to conventional radiotherapy in T1-2N0 laryngeal carcinoma Journal Article
| Authors: | Zumsteg, Z. S.; Riaz, N.; Jaffery, S.; Hu, M.; Gelblum, D.; Zhou, Y.; Mychalczak, B.; Zelefsky, M. J.; Wolden, S.; Rao, S.; Lee, N. Y. |
| Article Title: | Carotid sparing intensity-modulated radiation therapy achieves comparable locoregional control to conventional radiotherapy in T1-2N0 laryngeal carcinoma |
| Abstract: | Background Although intensity-modulated radiotherapy (IMRT) is a standard of care for many head and neck cancers, its use for carotid-sparing (CS) therapy in early-stage laryngeal carcinoma is controversial. Methods 330 consecutive patients with early-stage laryngeal carcinoma were treated from 1/1989 to 5/2011, including 282 conventional radiotherapy (CRT) and 48 CS-IMRT patients. The median follow-up was 43 (CS-IMRT) and 66 (CRT) months. Results There was no difference in local failure rates comparing patients undergoing CS-IMRT with CRT, with 3-year local control rates of 88% vs. 89%, respectively (p = 0.938). Using a 1 cm circumferential margin, the average dose to the left and right carotid arteries was 48.3 and 47.9 Gy, respectively. 88% of locoregional recurrences involved the ipsilateral true vocal cord, including all local recurrences in the IMRT group. Conclusions These results warrant further prospective evaluation of CS-IMRT for early-stage glottic larynx cancer. © 2015 Elsevier Ltd. All rights reserved. |
| Keywords: | imrt; carotid sparing; early stage laryngeal carcinoma; glottic cancer |
| Journal Title: | Oral Oncology |
| Volume: | 51 |
| Issue: | 7 |
| ISSN: | 1368-8375 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2015-07-01 |
| Start Page: | 716 |
| End Page: | 723 |
| Language: | English |
| DOI: | 10.1016/j.oraloncology.2015.02.003 |
| PROVIDER: | scopus |
| PUBMED: | 25958831 |
| PMCID: | PMC5508531 |
| DOI/URL: | |
| Notes: | Export Date: 2 July 2015 -- Source: Scopus |
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