Repeatability investigation of reduced field-of-view diffusion-weighted magnetic resonance imaging on thyroid glands Journal Article
| Authors: | Lu, Y.; Hatzoglou, V.; Banerjee, S.; Stambuk, H. E.; Gonen, M.; Shankaranarayanan, A.; Mazaheri, Y.; Deasy, J. O.; Shaha, A. R.; Tuttle, R. M.; Shukla-Dave, A. |
| Article Title: | Repeatability investigation of reduced field-of-view diffusion-weighted magnetic resonance imaging on thyroid glands |
| Abstract: | Objective To investigate the repeatability of the quantitative magnetic resonance imaging (MRI) metric (apparent diffusion coefficient [ADC]) derived from reduced field-of-view diffusion-weighted (rFOV DWI) on thyroid glands in a clinical setting. Materials and Methods Ten healthy human volunteers were enrolled in MRI studies performed on a 3-T MRI scanner. Each volunteer was designed to undergo 3 longitudinal examinations (2 weeks apart) with 2 repetitive sessions within each examination, which included rFOV and conventional full field-of-view (fFOV) DWI scans. Diffusion-weighted images were assessed and scored based on image characteristics. Apparent diffusion coefficient values of thyroid glands from all participants were calculated based on regions of interest. Repeatability analysis was performed based on the framework proposed by the Quantitative Imaging Biomarker Alliance, generating 4 repeatability metrics: within-participant variance (), repeatability coefficients, intraclass correlation coefficient, and within-participant coefficient of variation. Student t test was used to compare the performance difference between rFOV and fFOV DWI. Results The overall image quality from rFOV DWI was significantly higher than that from fFOV DWI (P = 0.04). The ADC values calculated from rFOV DWI were significantly lower than corresponding values from fFOV DWI (P < 0.001). There was no significant difference in ADC values across sessions and examinations in either rFOV or fFOV DWI (P > 0.05). Reduced field-of-view DWI had lower values of, repeatability coefficient, and within-participant coefficient of variation and had a higher value of intraclass correlation coefficient compared with fFOV DWI across either sessions or examinations. Conclusions This study demonstrated that rFOV DWI produced more superior-quality DWI images and more repeatable ADC measurements compared with fFOV DWI, thus providing a feasible quantitative imaging tool for investigating thyroid glands in clinical settings. © 2015 Wolters Kluwer Health, Inc. |
| Keywords: | adult; controlled study; prospective study; controlled clinical trial; correlation coefficient; image quality; thyroid gland; diffusion weighted imaging; diffusion coefficient; normal human; human experiment; nuclear magnetic resonance scanner; repeatability; imaging phantom; human; male; female; priority journal; article; reduced field-of-view diffusion-weighted imaging; thyroid glands; measurement repeatability |
| Journal Title: | Journal of Computer Assisted Tomography |
| Volume: | 39 |
| Issue: | 3 |
| ISSN: | 0363-8715 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2015-05-01 |
| Start Page: | 334 |
| End Page: | 339 |
| Language: | English |
| DOI: | 10.1097/rct.0000000000000227 |
| PROVIDER: | scopus |
| PMCID: | PMC4433417 |
| PUBMED: | 25700226 |
| DOI/URL: | |
| Notes: | Export Date: 2 July 2015 -- Source: Scopus |
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