A phase 2 study of bortezomib in combination with ifosfamide/vinorelbine in paediatric patients and young adults with refractory/recurrent Hodgkin lymphoma: A Children's Oncology Group study Journal Article
| Authors: | Horton, T. M.; Drachtman, R. A.; Chen, L.; Cole, P. D.; McCarten, K.; Voss, S.; Guillerman, R. P.; Buxton, A.; Howard, S. C.; Hogan, S. M.; Sheehan, A. M.; López-Terrada, D.; Mrazek, M. D.; Agrawal, N.; Wu, M. F.; Liu, H.; De Alarcon, P. A.; Trippett, T. M.; Schwartz, C. L. |
| Article Title: | A phase 2 study of bortezomib in combination with ifosfamide/vinorelbine in paediatric patients and young adults with refractory/recurrent Hodgkin lymphoma: A Children's Oncology Group study |
| Abstract: | A Children's Oncology Group clinical trial aimed to determine if bortezomib (B) increased the efficacy of ifosfamide and vinorelbine (IV) in paediatric Hodgkin lymphoma (HL). This study enrolled 26 relapsed HL patients (<30 years) treated with two to four cycles of IVB. The primary endpoint was anatomic complete response (CR) after two cycles. Secondary endpoints included overall response (OR: CR + partial response) at study completion compared to historical controls [72%; 95% confidence interval (CI): 59-83%]. Although few patients achieved the primary objective, OR with IVB improved to 83% (95% CI: 61-95%; p = 0·32). Although not statistically different, results suggest IVB may be a promising combination. © 2015 John Wiley & Sons Ltd. |
| Keywords: | clinical trials; nf-κb; childhood haematological malignancies; paediatric oncology |
| Journal Title: | British Journal of Haematology |
| Volume: | 170 |
| Issue: | 1 |
| ISSN: | 0007-1048 |
| Publisher: | John Wiley & Sons |
| Date Published: | 2015-07-01 |
| Start Page: | 118 |
| End Page: | 122 |
| Language: | English |
| DOI: | 10.1111/bjh.13388 |
| PROVIDER: | scopus |
| PMCID: | PMC4478135 |
| PUBMED: | 25833390 |
| DOI/URL: | |
| Notes: | Export Date: 2 July 2015 -- Source: Scopus |
