Secondary acute lymphoblastic leukaemia is constitutional and probably not related to prior therapy Journal Article
| Authors: | Ganzel, C.; Devlin, S.; Douer, D.; Rowe, J. M.; Stein, E. M.; Tallman, M. S. |
| Article Title: | Secondary acute lymphoblastic leukaemia is constitutional and probably not related to prior therapy |
| Abstract: | Very little is known about secondary acute lymphoblastic leukaemia (s-ALL). This retrospective analysis studied a cohort of s-ALL patients treated at a single centre between 1994 and 2013, while comparing therapy-associated ALL (t-ALL) and antecedent malignancy ALL (am-ALL) patients. Thirty-two patients with s-ALL were identified. The overall incidence was 9·4% among ALL adults while T-cell s-ALL was rare (12% of s-ALLs). The median time interval between two malignant diagnoses was 5·3 years (range: 0·1-28). In contrast to previous reports, most of the s-ALLs were CD10 + and without KMT2A (MLL) abnormalities. The overall survival (OS) rates of the entire cohort at 12 and 24 months from ALL diagnosis was 49% and 25%, respectively. Most patients (n = 23, 72%) received prior chemo-/radio-therapy for their first malignancy (t-ALL) and only 9 (28%) did not (am-ALL). No significant difference was found in the incidence of B-/T- lineage ALL, extramedullary disease, blood count, and the rate of Philadelphia-positive ALL, nor in the rates of complete remission (P = 0·55) and OS (P = 0·97). This similarity, together with high incidence of family malignancy in both groups, raise the possibility that s-ALL patients may have an inherent predisposition to malignancies and a history of previous therapy may be of lesser importance in the pathogenesis of s-ALL. © 2015 John Wiley & Sons Ltd. |
| Keywords: | therapy; acute lymphoblastic leukaemia; acute leukaemia; secondary acute lymphoblastic leukaemia; therapy related acute lymphoblastic leukaemia |
| Journal Title: | British Journal of Haematology |
| Volume: | 170 |
| Issue: | 1 |
| ISSN: | 0007-1048 |
| Publisher: | John Wiley & Sons |
| Date Published: | 2015-07-01 |
| Start Page: | 50 |
| End Page: | 55 |
| Language: | English |
| DOI: | 10.1111/bjh.13386 |
| PROVIDER: | scopus |
| PUBMED: | 25823602 |
| DOI/URL: | |
| Notes: | Export Date: 2 July 2015 -- Source: Scopus |
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