Evaluation of initial telomere length and changes after transplantation in adult double-unit cord blood transplant recipients Journal Article

   


Authors: Ashbridge, B.; Zehir, A.; Lubin, M.; Barker, J. N.; Moore, M. A. S.
Article Title: Evaluation of initial telomere length and changes after transplantation in adult double-unit cord blood transplant recipients
Abstract: Cord blood (CB) leukocytes have inherent telomere length (TL) variation, and CB hematopoietic stem cells (HSC) can maintain high telomerase levels preventing telomere attrition invitro. We evaluated TL changes in 13 adult double-unit CB transplant (CBT) recipients. In the 26 units, we observed a marked variation in CB TL at thaw (median, 9.99 kilobases [kb]; range, 6.85 to 13.5). All 13 patients engrafted. Of 11 engrafting with 1 unit, there was no correlation between unit dominance and TL (mean dominant unit TL, 8.84 kb ± 1.76; mean nonengrafting unit TL, 10.3 kb ± 1.81; P= .77). Serial measurements of TL up to 1 year after CBT demonstrated an overall mean 3.04 kb ± .16 TL decrease with only 1 patient exhibiting telomere maintenance. In summary, initial TL does not predict CB unit dominance. Moreover, our analysis suggests neonatal hematopoiesis makes a transition to an HSC characterized by changes in average TL and potentially low telomerase asymmetric cell division in adult CBT recipients. Further investigation of alterations in telomere length and its clinical implications after transplantation of this observation are indicated. © 2015 American Society for Blood and Marrow Transplantation.
Keywords: adult; clinical article; follow up; cell viability; telomerase; cord blood; cord blood stem cell transplantation; engraftment; hematologic malignancy; donor; hematopoiesis; graft recipient; recipient; allogeneic transplantation; tumor microenvironment; short tandem repeat; telomere length; telomere homeostasis; telomere shortening; human; article
Journal Title: Biology of Blood and Marrow Transplantation
Volume: 21
Issue: 7
ISSN: 1083-8791
Publisher: Elsevier Inc.  
Date Published: 2015-07-01
Start Page: 1334
End Page: 1336
Language: English
DOI: 10.1016/j.bbmt.2015.04.006
PROVIDER: scopus
PMCID: PMC4466009
PUBMED: 25865647
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-84930581779&partnerID=40&md5=92958c3dc6e735e6e797eec373f1e497
Notes: Export Date: 2 July 2015 -- Source: Scopus
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MSK Authors
  1. Juliet N Barker
    335 Barker
  2. Ahmet Zehir
    343 Zehir
  3. Malcolm A S Moore
    549 Moore
  4. Beth Ashbridge
    5 Ashbridge
  5. Marissa N Lubin
    79 Lubin
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