Loss of PTEN leads to clinical resistance to the PI3K alpha inhibitor BYL719 and provides evidence of convergent evolution under selective therapeutic pressure Meeting Abstract


Authors: Castel, P.; Juric, D.; Won, H.; Ainscough, B.; Ellis, H.; Ebbesen, S.; Griffith, M.; Griffith, O.; Iyer, G.; Sgroi, D.; Isakoff, S.; Mardis, E.; Solit, D.; Lowe, S.; Quadt, C.; Peters, M.; Berger, M.; Scaltriti, M.; Baselga, J.
Abstract Title: Loss of PTEN leads to clinical resistance to the PI3K alpha inhibitor BYL719 and provides evidence of convergent evolution under selective therapeutic pressure
Meeting Title: 105th Annual Meeting of the American Association for Cancer Research (AACR)
Journal Title: Cancer Research
Volume: 74
Issue: 19 Suppl.
Meeting Dates: 2014 Apr 5-9
Meeting Location: San Diego, CA
ISSN: 0008-5472
Publisher: American Association for Cancer Research  
Date Published: 2014-10-01
Language: English
ACCESSION: WOS:000349910205363
DOI: 10.1158/1538-7445.am2014-lb-327
PROVIDER: wos
Notes: Meeting Abstract: LB-327 -- 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR) -- APR 05-09, 2014 -- San Diego, CA -- S -- Source: Wos
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MSK Authors
  1. David Solit
    778 Solit
  2. Gopakumar Vasudeva Iyer
    342 Iyer
  3. Michael Forman Berger
    764 Berger
  4. Scott W Lowe
    249 Lowe
  5. Helen Hyeong-Eun Won
    109 Won
  6. Pau Castel
    25 Castel
  7. Jose T Baselga
    484 Baselga
  8. Maurizio Scaltriti
    169 Scaltriti
  9. Haley Lynn Ellis
    7 Ellis