Caenorhabditis elegans as a model to study sphingolipid signaling Journal Article


Authors: Deng, X.; Kolesnick, R.
Article Title: Caenorhabditis elegans as a model to study sphingolipid signaling
Abstract: Sphingolipid signaling in Caenorhabditis elegans is vital for sensing environmental change and effecting appropriate cellular response. Many molecular components in sphingolipid intermediary metabolism are conserved throughout evolution. Here we review use of C. elegans as a model system for conducting sphingolipid-based scientific investigation, which has helped us better understand vital roles these remarkable lipids play in human metabolism and disease.
Keywords: biosynthesis; presynaptic terminals; caenorhabditis elegans; sphingolipids; synthesis; ceramide; glycosphingolipid; recruitment; ceramide synthase; c-elegans; sphingosine 1-phosphate; sphingosine-1-phosphate; programmed cell-death; cgt; spt; branched-chain
Journal Title: Biological Chemistry
Volume: 396
Issue: 6-7
ISSN: 1431-6730
Publisher: Walter de Gruyter GmbH  
Date Published: 2015-06-01
Start Page: 767
End Page: 773
Language: English
ACCESSION: WOS:000353947200017
DOI: 10.1515/hsz-2014-0298
PROVIDER: wos
PUBMED: 25720116
Notes: Review -- Source: Wos
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MSK Authors
  1. Richard N Kolesnick
    235 Kolesnick
  2. Xinzhu Deng
    10 Deng