Caenorhabditis elegans as a model to study sphingolipid signaling Journal Article
| Authors: | Deng, X.; Kolesnick, R. |
| Article Title: | Caenorhabditis elegans as a model to study sphingolipid signaling |
| Abstract: | Sphingolipid signaling in Caenorhabditis elegans is vital for sensing environmental change and effecting appropriate cellular response. Many molecular components in sphingolipid intermediary metabolism are conserved throughout evolution. Here we review use of C. elegans as a model system for conducting sphingolipid-based scientific investigation, which has helped us better understand vital roles these remarkable lipids play in human metabolism and disease. |
| Keywords: | biosynthesis; presynaptic terminals; caenorhabditis elegans; sphingolipids; synthesis; ceramide; glycosphingolipid; recruitment; ceramide synthase; c-elegans; sphingosine 1-phosphate; sphingosine-1-phosphate; programmed cell-death; cgt; spt; branched-chain |
| Journal Title: | Biological Chemistry |
| Volume: | 396 |
| Issue: | 6-7 |
| ISSN: | 1431-6730 |
| Publisher: | Walter de Gruyter GmbH |
| Date Published: | 2015-06-01 |
| Start Page: | 767 |
| End Page: | 773 |
| Language: | English |
| ACCESSION: | WOS:000353947200017 |
| DOI: | 10.1515/hsz-2014-0298 |
| PROVIDER: | wos |
| PUBMED: | 25720116 |
| Notes: | Review -- Source: Wos |
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