Effects of a green tea extract, Polyphenon E, on systemic biomarkers of growth factor signalling in women with hormone receptor-negative breast cancer Journal Article
| Authors: | Crew, K. D.; Ho, K. A.; Brown, P.; Greenlee, H.; Bevers, T. B.; Arun, B.; Sneige, N.; Hudis, C.; Mcarthur, H. L.; Chang, J.; Rimawi, M.; Cornelison, T. L.; Cardelli, J.; Santella, R. M.; Wang, A.; Lippman, S. M.; Hershman, D. L. |
| Article Title: | Effects of a green tea extract, Polyphenon E, on systemic biomarkers of growth factor signalling in women with hormone receptor-negative breast cancer |
| Abstract: | Background: Observational and experimental data support a potential breast cancer chemopreventive effect of green tea. Methods: We conducted an ancillary study using archived blood/urine from a phase IB randomised, placebo-controlled dose escalation trial of an oral green tea extract, Polyphenon E (Poly E), in breast cancer patients. Using an adaptive trial design, women with stage I-III breast cancer who completed adjuvant treatment were randomised to Poly E 400 mg (n = 16), 600 mg (n = 11) and 800 mg (n = 3) twice daily or matching placebo (n = 10) for 6 months. Blood and urine collection occurred at baseline, and at 2, 4 and 6 months. Biological endpoints included growth factor [serum hepatocyte growth factor (HGF), vascular endothelial growth factor (VEGF)], lipid (serum cholesterol, triglycerides), oxidative damage and inflammatory biomarkers. Results: From July 2007-August 2009, 40 women were enrolled and 34 (26 Poly E, eight placebo) were evaluable for biomarker endpoints. At 2 months, the Poly E group (all dose levels combined) compared to placebo had a significant decrease in mean serum HGF levels (-12.7% versus +6.3%, P = 0.04). This trend persisted at 4 and 6 months but was no longer statistically significant. For the Poly E group, serum VEGF decreased by 11.5% at 2 months (P = 0.02) and 13.9% at 4 months (P = 0.05) but did not differ compared to placebo. At 2 months, there was a trend toward a decrease in serum cholesterol with Poly E (P = 0.08). No significant differences were observed for other biomarkers. Conclusions: Our findings suggest potential mechanistic actions of tea polyphenols in growth factor signalling, angiogenesis and lipid metabolism. © 2014 The British Dietetic Association Ltd. |
| Keywords: | breast cancer; chemoprevention; tea polyphenols |
| Journal Title: | Journal of Human Nutrition and Dietetics |
| Volume: | 28 |
| Issue: | 3 |
| ISSN: | 0952-3871 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2015-06-01 |
| Start Page: | 272 |
| End Page: | 282 |
| Language: | English |
| DOI: | 10.1111/jhn.12229 |
| PROVIDER: | scopus |
| PMCID: | PMC4205214 |
| PUBMED: | 24646362 |
| DOI/URL: | |
| Notes: | Export Date: 3 June 2015 -- Source: Scopus |
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