Lung transplantation after allogeneic marrow transplantation in pediatric patients: The Memorial Sloan-Kettering experience Journal Article

Authors: Heath, J. A.; Kurland, G.; Spray, T. L.; Kernan, N. A.; Small, T. N.; Brochstein, J. A.; Gillio, A. P.; Boklan, J.; O'Reilly, R. J.; Boulad, F.
Article Title: Lung transplantation after allogeneic marrow transplantation in pediatric patients: The Memorial Sloan-Kettering experience
Abstract: Background. Chronic lung disease and pulmonary failure are complications that can occur after bone marrow transplantation (BMT) and are associated with severe morbidity and mortality. Methods. We report on four patients who developed chronic, progressive, and irreversible lung disease 1 to 3 years after allogeneic BMT in childhood. These patients had chronic graft-versus-host disease (n=3) or radiation-related pulmonary fibrosis (n=1). Three patients underwent double lung transplants and one patient underwent a single lung transplant 2 to 14 years after BMT. Results. All four patients tolerated the lung transplantation procedure well and showed significant clinical improvement with normalization of pulmonary function tests by 1 year posttransplant. One patient died from infectious complications 3 years after lung transplantation, and one patient died after chronic rejection of the transplanted lungs 6 years posttransplant. Two patients remain alive without significant respiratory impairment 2 and 7 years after lung transplantation. Conclusion. We conclude that lung transplantation offers a viable therapeutic option for patients who develop respiratory failure secondary to BMT.
Keywords: adolescent; adult; child; treatment outcome; child, preschool; transplantation, homologous; case report; disease association; allogenic bone marrow transplantation; postoperative complication; graft versus host reaction; postoperative infection; graft survival; bone marrow transplantation; fatal outcome; lung transplantation; lung diseases; lung insufficiency; humans; human; male; female; priority journal; article; chronic lung disease
Journal Title: Transplantation
Volume: 72
Issue: 12
ISSN: 0041-1337
Publisher: Lippincott Williams & Wilkins  
Date Published: 2001-12-27
Start Page: 1986
End Page: 1990
Language: English
PUBMED: 11773900
PROVIDER: scopus
DOI: 10.1097/00007890-200112270-00020
Notes: Export Date: 21 May 2015 -- Source: Scopus
Citation Impact
MSK Authors
  1. Nancy Kernan
    505 Kernan
  2. Trudy Small
    234 Small
  3. Farid Boulad
    326 Boulad
  4. John A Heath
    4 Heath
  5. Jessica Boklan
    4 Boklan
  6. Richard O'Reilly
    733 O'Reilly
  7. Alfred P. Gillio
    89 Gillio