Tumor therapy with targeted atomic nanogenerators Journal Article
| Authors: | McDevitt, M. R.; Ma, D.; Lai, L. T.; Simon, J.; Borchardt, P.; Frank, R. K.; Wu, K.; Pellegrini, V.; Curcio, M. J.; Miederer, M.; Bander, N. H.; Scheinberg, D. A. |
| Article Title: | Tumor therapy with targeted atomic nanogenerators |
| Abstract: | A single, high linear energy transfer alpha particle can kill a target cell. We have developed methods to target molecular-sized generators of alpha-emitting isotope cascades to the inside of cancer cells using actinium-225 coupled to internalizing monoclonal antibodies. In vitro, these constructs specifically killed leukemia, lymphoma, breast, ovarian, neuroblastoma, and prostate cancer cells at becquerel (picocurie) levels. Injection of single doses of the constructs at kilobecquerel (nanocurie) levels into mice bearing solid prostate carcinoma or disseminated human lymphoma induced tumor regression and prolonged survival, without toxicity, in a substantial fraction of animals, Nanogenerators targeting a wide variety of cancers may be possible. |
| Keywords: | cancer survival; survival rate; unclassified drug; nonhuman; neoplasms; isotopes; animal cell; mouse; animals; mice; tumor regression; tumor cells, cultured; cancer therapy; animalia; monoclonal antibody; prostate-specific antigen; prostatic neoplasms; antibodies, monoclonal; mice, nude; tumors; cancer cell; lymphoma; energy transfer; antibodies; neoplasm transplantation; toxicity; radioimmunotherapy; medicine; isotope; drug delivery system; half-life; cell killing; cells; immunoconjugates; alpha particles; actinium; heterocyclic compounds, 1-ring; linear energy transfer; astatine 211; monoclonal antibody m 195; humans; male; female; priority journal; article; atomic particle; nanogenerators; monoclonal antibody b 4; monoclonal antibody j 591 |
| Journal Title: | Science |
| Volume: | 294 |
| Issue: | 5546 |
| ISSN: | 0036-8075 |
| Publisher: | American Association for the Advancement of Science |
| Date Published: | 2001-11-16 |
| Start Page: | 1537 |
| End Page: | 1540 |
| Language: | English |
| DOI: | 10.1126/science.1064126 |
| PUBMED: | 11711678 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 21 May 2015 -- Source: Scopus |
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