A strategy for probing the autonomy of cross-domain stereochemical communication in glycoconjugates Journal Article
| Authors: | Live, D. H.; Wang, Z. G.; Iserloh, U.; Danishefsky, S. J. |
| Article Title: | A strategy for probing the autonomy of cross-domain stereochemical communication in glycoconjugates |
| Abstract: | matrix presented Glycoproteins contain carbohydrate and peptide sectors. As a model for studying whether there exists stereochemical "communication" between the two domains, we prepared two glycopeptides differing only in the absolute stereochemistry of the peptide domain (L-peptide vs D-peptide). High-field NMR spectroscopy revealed that there are distinct and measurable differences, indicating that the two domains are at some level interactive. |
| Keywords: | molecular genetics; peptide; chemistry; molecular sequence data; peptides; models, molecular; chemical structure; conformation; glycoproteins; glycoprotein; synthesis; carbohydrate analysis; carbohydrate sequence; glycopeptide; glycopeptides; glycoconjugate; carbohydrate conformation; glycoconjugates; article |
| Journal Title: | Organic Letters |
| Volume: | 3 |
| Issue: | 6 |
| ISSN: | 1523-7060 |
| Publisher: | American Chemical Society |
| Date Published: | 2001-03-22 |
| Start Page: | 851 |
| End Page: | 853 |
| Language: | English |
| DOI: | 10.1021/ol0070233 |
| PUBMED: | 11263898 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 21 May 2015 -- Source: Scopus |
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