Histone deacetylases and cancer: Causes and therapies Journal Article
| Authors: | Marks, P. A.; Rifkind, R. A.; Richon, V. M.; Breslow, R.; Miller, T.; Kelly, W. K. |
| Article Title: | Histone deacetylases and cancer: Causes and therapies |
| Abstract: | Together, histone acetyltransferases and histone deacetylases (HDACs) determine the acetylation status of histones. This acetylation affects the regulation of gene expression, and inhibitors of HDACs have been found to cause growth arrest, differentiation and/or apoptosis of many tumours cells by altering the transcription of a small number of genes. HDAC inhibitors are proving to be an exciting therapeutic approach to cancer, but how do they exert this effect? |
| Keywords: | clinical trial; review; antineoplastic agents; comparative study; antineoplastic agent; neoplasm; neoplasms; animal; metabolism; animals; cell cycle; apoptosis; classification; neoplasm proteins; transcription factor; drug effect; drug screening; enzymology; drug screening assays, antitumor; enzyme inhibitor; physiology; transcription factors; gene expression regulation; gene expression regulation, neoplastic; drug antagonism; protein processing; protein processing, post-translational; species specificity; saccharomyces cerevisiae; enzyme inhibitors; histone; chromatin; tumor protein; transactivation; neoplasms, experimental; forecasting; species difference; models, molecular; chemical structure; gene silencing; experimental neoplasm; saccharomyces cerevisiae proteins; saccharomyces cerevisiae protein; histones; histone deacetylases; ultrastructure; clinical trials; histone deacetylase; acetylation; nucleosome; nucleosomes; trans-activation (genetics); humans; human; male; female |
| Journal Title: | Nature Reviews Cancer |
| Volume: | 1 |
| Issue: | 3 |
| ISSN: | 1474-175X |
| Publisher: | Nature Publishing Group |
| Date Published: | 2001-12-01 |
| Start Page: | 194 |
| End Page: | 202 |
| Language: | English |
| PUBMED: | 11902574 |
| PROVIDER: | scopus |
| DOI: | 10.1038/35106079 |
| DOI/URL: | |
| Notes: | Export Date: 21 May 2015 -- Source: Scopus |
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