Adult perineal sarcomas Journal Article

Authors: Grobmyer, S. R.; Clary, B.; Lewis, J. J.; Delgado, R.; Woodruff, J. M.; Brennan, M. F.
Article Title: Adult perineal sarcomas
Abstract: Background and Objectives: Primary perineal sarcoma in adults is a rare disease that has only been documented to occur in isolated case reports. Methods: To better characterize and define the natural history of perineal sarcoma in adults (≥18 years), we reviewed our experience with treatment of perineal sarcoma between 1982 and 1999 (nine cases). Results: Epithelioid sarcoma (n=4) was the most common histologic subtype. Seven cases (78%) were histologically high grade, and lesions were most commonly <5 cm. All patients were treated with wide local excision. External beam radiation was the most commonly used form of adjuvant therapy (n=6). Recurrences were noted in five patients, and the recurrences were most commonly local (60%). Median time to first recurrence was 21 months. Six of nine patients are alive with a median follow-up of 54 months. Three died of recurrent/metastatic disease at 16, 51, and 54 months after initial surgery. Conclusions: Aggressive therapy and follow-up beginning with wide excision can be associated with long-term survival in adults with primary perineal sarcoma. © 2001 Wiley-Liss, Inc.
Keywords: adolescent; adult; cancer survival; clinical article; treatment outcome; aged; middle aged; cancer surgery; cancer localization; cancer radiotherapy; radiotherapy, adjuvant; neoplasm recurrence, local; sarcoma; soft tissue sarcoma; surgery; radiation therapy; soft tissue neoplasms; perineum; humans; human; male; female; priority journal; article
Journal Title: Journal of Surgical Oncology
Volume: 77
Issue: 2
ISSN: 0022-4790
Publisher: Wiley Blackwell  
Date Published: 2001-06-01
Start Page: 101
End Page: 104
Language: English
DOI: 10.1002/jso.1078
PUBMED: 11398162
PROVIDER: scopus
Notes: Export Date: 21 May 2015 -- Source: Scopus
Citation Impact
MSK Authors
  1. Murray F Brennan
    1000 Brennan
  2. Jonathan J Lewis
    109 Lewis
  3. Ruby Delgado
    26 Delgado
  4. Bryan M Clary
    7 Clary
  5. James M Woodruff
    161 Woodruff